Use of Oral Fluid to Examine the Molecular Epidemiology of Varicella Zoster Virus in the United Kingdom and Continental Europe

We investigated oral fluid (OF) as an alternative to sampling of rashes for varicella zoster virus (VZV) genotyping and further characterized VZV clade prevalence in the United Kingdom and Europe. VZV was detected in up to 91% of OF specimens. Paired OF and vesicle fluid samples contained identical...

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Bibliographic Details
Published in:The Journal of infectious diseases 2013-02, Vol.207 (4), p.588-593
Main Authors: Quinlivan, Mark, Sengupta, Nitu, Papaevangelou, Vassiliki, Sauerbrei, Andreas, Grillner, Lena, Rousseva, Rossitsa, Hague, Rosie, Lutsar, Irja, Jogi, Piia, Leca, Ana, Grytchol, Ruth, Alain, Sophie, Breuer, Judith
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chickenpox - epidemiology
Chickenpox - virology
Europe - epidemiology
Fundamental and applied biological sciences. Psychology
Genotype
Herpes Zoster - epidemiology
Herpes Zoster - virology
Herpesvirus 3, Human - genetics
Herpesvirus 3, Human - isolation & purification
Humans
Infectious diseases
Major and Brief Reports
MAJOR ARTICLES AND BRIEF REPORTS
Medical sciences
Microbiology
Miscellaneous
Molecular Epidemiology
Mouth - virology
Polymorphism, Single Nucleotide
Prevalence
Saliva - virology
Sensitivity and Specificity
Skin - pathology
Skin - virology
United Kingdom - epidemiology
Varicella-zoster virus
Virology
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Summary:We investigated oral fluid (OF) as an alternative to sampling of rashes for varicella zoster virus (VZV) genotyping and further characterized VZV clade prevalence in the United Kingdom and Europe. VZV was detected in up to 91% of OF specimens. Paired OF and vesicle fluid samples contained identical VZV clades. While clades 1 and 3 were the most prevalent across the United Kingdom and Europe, in Western Europe, clade 5 viruses were circulating. Viruses from the same outbreak belonged to different clades, but no clade was associated with a severe-disease phenotype. OF is suitable and convenient for large-scale molecular epidemiological studies of VZV.
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jis649