Influence of radiotherapy for the first tumor on aggressiveness of contralateral breast cancer

We aimed to investigate if characteristics of contralateral breast cancer (CBC) are influenced by adjuvant radiotherapy for the first breast cancer. Using information from population‐based registers and medical records, we analyzed two cohorts comprising all women with CBC diagnosed >3 months aft...

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Bibliographic Details
Published in:International journal of cancer 2013-05, Vol.132 (10), p.2388-2394
Main Authors: Sandberg, Maria E.C., Alkner, Sara, Hartman, Mikael, Eloranta, Sandra, Rydén, Lisa, Ploner, Alexander, Adami, Hans‐Olov, Hall, Per, Czene, Kamila
Format: Article
Language:English
Subjects:
adjuvant radiotherapy
Adult
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Cancer
Cancer and Oncology
cancer epidemiology
Cancer och onkologi
Clinical Medicine
Cohort Studies
Confidence intervals
contralateral breast cancer (CBC)
Female
Gynecology. Andrology. Obstetrics
Humans
Incidence
Klinisk medicin
Mammary gland diseases
Medical and Health Sciences
Medical research
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Neoplasm Grading
Neoplasm Staging
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - etiology
Neoplasms, Second Primary - pathology
Odds Ratio
Poisson Distribution
Prognosis
Radiation therapy
Radiotherapy Dosage
Radiotherapy, Adjuvant - adverse effects
Risk factors
Sweden - epidemiology
tumor characteristics
Tumors
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Summary:We aimed to investigate if characteristics of contralateral breast cancer (CBC) are influenced by adjuvant radiotherapy for the first breast cancer. Using information from population‐based registers and medical records, we analyzed two cohorts comprising all women with CBC diagnosed >3 months after their first cancer (809 patients in Stockholm 1976–2005 and 750 patients in South Sweden 1977–2005). We used Poisson regression to calculate risk of distant metastasis after CBC, comparing patients treated and not treated with radiotherapy for the first cancer. Logistic regression was used to estimate odds ratio (OR) of more aggressive tumor characteristics in the second cancer, compared to the first. For patients with CBC in Stockholm with
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.27890