Crosstalk of the plasma contact system with bacteria

Abstract Activation of the plasma contact system triggers several cascade systems such as the kallikrein-kinin system, the intrinsic pathway of coagulation, the classical complement cascade and the fibrinolytic system. Recent studies have shown a critical role of the contact system for arterial and...

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Bibliographic Details
Published in:Thrombosis research 2012-10, Vol.130, p.S78-S83
Main Authors: Nickel, Katrin Faye, Renné, Thomas
Format: Article
Language:English
Subjects:
Animals
Bacteria - immunology
Bacteria - metabolism
Bacterial Infections - blood
Bacterial Infections - complications
Bacterial Infections - immunology
Bacterial Infections - microbiology
Blood Coagulation
Bradykinin
Capillary Permeability
Coagulation
Complement Pathway, Classical
Factor XII
Fibrin - metabolism
Fibrinolysis
Hematology, Oncology and Palliative Medicine
Humans
Immunity, Innate
Infectious diseases
Innate immunity
Kallikrein-Kinin System
Plasma contact system
Sepsis - blood
Sepsis - immunology
Sepsis - microbiology
Signal Transduction
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Summary:Abstract Activation of the plasma contact system triggers several cascade systems such as the kallikrein-kinin system, the intrinsic pathway of coagulation, the classical complement cascade and the fibrinolytic system. Recent studies have shown a critical role of the contact system for arterial and venous thrombus formation and thromboembolic disease. In contrast, the function of the contact system for host-defense reactions and its physiological functions have remained enigmatic. Experimental animal studies and clinical data have linked the contact system to bacterial infections with implications for sepsis disease. The present review summarizes the role of the contact system and its activation for bacterial infections.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2012.08.284