Atrazine and cancer: a review of the epidemiologic evidence

The aim of this study was to evaluate the conflicting reports from the Environmental Protection Agency and the Scientific Advisory Panel (Panel) on the carcinogenicity of atrazine in order to determine whether the results from epidemiologic studies support a causal relationship between atrazine and...

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Published in:European journal of cancer prevention 2013-03, Vol.22 (2), p.169-180
Main Authors: Boffetta, Paolo, Adami, Hans-Olov, Berry, Colin, Mandel, Jack S.
Format: Article
Language:English
Subjects:
Animals
Atrazine - administration & dosage
Atrazine - toxicity
Biological and medical sciences
Case-Control Studies
Environmental Exposure - adverse effects
Epidemiologic Studies
Evidence-Based Medicine
Herbicides - administration & dosage
Herbicides - toxicity
Humans
Medical sciences
Medicin och hälsovetenskap
Neoplasms - chemically induced
Neoplasms - diagnosis
Neoplasms - epidemiology
Review article
Tumors
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container_end_page 180
container_issue 2
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container_title European journal of cancer prevention
container_volume 22
creator Boffetta, Paolo
Adami, Hans-Olov
Berry, Colin
Mandel, Jack S.
description The aim of this study was to evaluate the conflicting reports from the Environmental Protection Agency and the Scientific Advisory Panel (Panel) on the carcinogenicity of atrazine in order to determine whether the results from epidemiologic studies support a causal relationship between atrazine and any specific cancer. We reviewed the Environmental Protection Agency and Panel reports in the context of all the epidemiologic studies on the specific cancers of interest. A weight-of-evidence approach leads to the conclusion that there is no causal association between atrazine and cancer and that occasional positive results can be attributed to bias or chance. Atrazine appears to be a good candidate for a category of herbicides with a probable absence of cancer risk. Atrazine should be treated for regulatory and public health purposes as an agent unlikely to pose a cancer risk to humans.
doi_str_mv 10.1097/CEJ.0b013e32835849ca
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identifier ISSN: 0959-8278
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subjects Animals
Atrazine - administration & dosage
Atrazine - toxicity
Biological and medical sciences
Case-Control Studies
Environmental Exposure - adverse effects
Epidemiologic Studies
Evidence-Based Medicine
Herbicides - administration & dosage
Herbicides - toxicity
Humans
Medical sciences
Medicin och hälsovetenskap
Neoplasms - chemically induced
Neoplasms - diagnosis
Neoplasms - epidemiology
Review article
Tumors
title Atrazine and cancer: a review of the epidemiologic evidence
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