Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice

• Published in: Neuroscience 2012-10, Vol.223, p.246-257
• Main Authors: Rojas, P, Ruiz-Sánchez, E, Rojas, C, Ögren, S.O
• Format: Article
• Language: English
• Subjects: Animals; Antiparkinson Agents - pharmacology; Antiparkinson Agents - therapeutic use; Brain - drug effects; Brain - metabolism; Disease Models, Animal; Dopamine - genetics; Dopamine - metabolism; Dopamine Plasma Membrane Transport Proteins - genetics; Dopamine Plasma Membrane Transport Proteins - metabolism; EGb 761; gene expression; Gene Expression Regulation - drug effects; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Male; Medicin och hälsovetenskap; Mice; Mice, Inbred C57BL; MPTP; Neurology; Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics; Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism; Nurr1; Parkinsonian Disorders - drug therapy; Parkinsonian Disorders - metabolism; Parkinsonian Disorders - pathology; Parkinson’s disease model; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D2 - metabolism; RNA, Messenger - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Tyrosine 3-Monooxygenase - genetics; Tyrosine 3-Monooxygenase - metabolism; Vesicular Monoamine Transport Proteins - genetics; Vesicular Monoamine Transport Proteins - metabolism
• ISSN: 0306-4522; 1873-7544; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.08.004

Highlights ► MPTP is widely used as a model for Parkinson’s disease. ► EGb761 is a well-defined mixture of active compounds extracted from Ginkgo biloba. ► EGb761 regulates dopamine-related genes altered by MPTP neurotoxicity. ► Tyrosine hydroxylase- and Nurr1- mRNA were regulated by EGb761. ► Neuroprotection of EGb761 in MPTP involves regulation of dopamine-related genes.