Fifty years in the thioredoxin field and a bountiful harvest

Discovered 50years ago as a hydrogen donor for the reduction of ribonucleotides, thioredoxin is currently recognized as a protein central to the regulation of multiple processes in the cell. Two meetings separated by a period of 30years serve as benchmarks for assessing this transition—the first hel...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2012-11, Vol.1820 (11), p.1822-1829
Main Authors: Buchanan, Bob B., Holmgren, Arne, Jacquot, Jean-Pierre, Scheibe, Renate
Format: Article
Language:English
Subjects:
Animals
chemical reduction
Chloroplasts - metabolism
Humans
hydrogen
Medicin och hälsovetenskap
Oxidation-Reduction
Oxidative Stress
proteins
Redox biology
Redox regulation
ribonucleotides
Thioredoxin
Thioredoxins - physiology
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Summary:Discovered 50years ago as a hydrogen donor for the reduction of ribonucleotides, thioredoxin is currently recognized as a protein central to the regulation of multiple processes in the cell. Two meetings separated by a period of 30years serve as benchmarks for assessing this transition—the first held in Berkeley (California) in 1981 and the other convened in 2011 in Sant Feliu de Guixols (Spain). The four of us contributing this article attended both meetings and thus have witnessed the development of the thioredoxin field and its notable extension in unanticipated new directions. In this Perspective we briefly recount the unfolding of this remarkable story. ► Commemoration of the 50th birthday of protein thioredoxin. ► Development of field traced from discovery in 1964 to 2011. ► Function expands from hydrogen carrier to regulatory protein acting throughout biology. ► Stockholm, Berkeley and Saint Feliu de Guixols conferences serve as benchmarks.
ISSN:0304-4165
0006-3002
1872-8006
DOI:10.1016/j.bbagen.2012.07.006