Impaired neutralizing activity by transplacental measles antibodies in infants born to HIV-1-infected mothers

Aim:  Growing numbers of newborns are saved from HIV infection through increased access to mother‐to‐child transmission prevention programmes. The maternally derived humoral immunity of these children might be impaired, both in terms of quantity and in terms of quality, with consequences for the tim...

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Bibliographic Details
Published in:Acta Paediatrica 2012-11, Vol.101 (11), p.e500-e504
Main Authors: Farouk, S, Navér, L, Smedman, L
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Blood Physiological Phenomena - immunology
Case-Control Studies
Children
Disease transmission
Enzyme-Linked Immunosorbent Assay
Female
HIV
HIV Infections - immunology
HIV-1 infection
Human immunodeficiency virus
Humans
Immunity, Humoral
Immunization
Infant
Infants
Infection
Infections
Male
Maternal antibodies
Measles
Measles immunization
Measles virus
Measles virus - immunology
Medicin och hälsovetenskap
Neonates
Neutralization test
Neutralization Tests - methods
Optical density
Pregnancy
Pregnancy Complications, Infectious - immunology
Prenatal Exposure Delayed Effects - blood
Prenatal Exposure Delayed Effects - immunology
Vaccines
Vero cells
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Summary:Aim:  Growing numbers of newborns are saved from HIV infection through increased access to mother‐to‐child transmission prevention programmes. The maternally derived humoral immunity of these children might be impaired, both in terms of quantity and in terms of quality, with consequences for the timing of immunization against measles. Methods:  A cell‐ELISA technique compared the neutralizing activity on Edmonston strain measles virus of sera from 1‐ to 4‐month‐old infants. Ten serum specimens came from noninfected infants of HIV‐infected mothers and another 10 from infants of healthy mothers. The sera were matched for the level of conventional ELISA measles antibodies. Results:  Reflecting infection of the Vero cells by non‐neutralized virus, optical density values were significantly higher for the sera from the children of the HIV‐infected mothers than for those of the noninfected mothers (p 
ISSN:0803-5253
1651-2227
1651-2227
DOI:10.1111/j.1651-2227.2012.02793.x