Motor, mental and behavioral developments in infancy are associated with fatty acid pattern in breast milk and plasma of premature infants

Abstract The objective of this study was to investigate any association between infants' early development and PUFA concentrations in early breast milk and infants' plasma phospholipids at 44 weeks gestational age. Fifty-one premature infants were included. The quality of general movement...

Full description

Saved in:
Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2012-04, Vol.86 (4), p.183-188
Main Authors: Sabel, K.-G, Strandvik, B, Petzold, M, Lundqvist-Persson, C
Format: Article
Language:English
Subjects:
Advanced Basic Science
age
Arachidonic acid
Bayley's Scales
brain
Breast Feeding
Child Development - physiology
Cognition - physiology
Docosahexaenoic acid
Endocrinology & Metabolism
Fatty Acids, Unsaturated
Female
fish-oil
General movements
Gestational Age
Humans
Infant
Infant Behavior - physiology
Infant, Newborn
Infant, Premature - growth & development
Linoleic acid
Male
Mead acid
Medicin och hälsovetenskap
Milk, Human - chemistry
movements
Pediatrics
Pediatrik
pregnancy
preterm infants
Psychology
Psykologi
Samhällsvetenskap
Social Sciences
supplementation
term infants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The objective of this study was to investigate any association between infants' early development and PUFA concentrations in early breast milk and infants' plasma phospholipids at 44 weeks gestational age. Fifty-one premature infants were included. The quality of general movement was assessed at 3 months, and motor, mental and behavioral development at 3, 6, 10 and 18 months corrected age using Bayley's Scales of Infant Development (BSID-II). Linoleic acid, the major n-6/n-3 FA ratios, Mead acid and the EFA deficiency index in early breast milk were negatively associated with development up to 18 months of age. DHA and AA, respectively, in infants' plasma phospholipids was positively, but the AA/DHA ratio negatively, associated with development from 6 to 18 months of age. Our data suggest that the commonly found high n-6 concentration in breast milk is associated with less favorable motor, mental and behavioral development up to 18 months of age.
ISSN:0952-3278
1532-2823
1532-2823
DOI:10.1016/j.plefa.2012.02.008