Filaggrin mutations increase the risk for persistent dry skin and eczema independent of sensitization

Proportions and odds ratios (ORs) are shown with 95% CIs. [...]tests for gene-environment interactions were performed between FLG mutations and presence of siblings or cat in the household at birth according to the information provided in the questionnaires. [...]our prospective study shows that FLG...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2012-04, Vol.129 (4), p.1153-1155
Main Authors: Böhme, Maria, MD, PhD, Söderhäll, Cilla, PhD, Kull, Inger, RN, PhD, Bergström, Anna, PhD, van Hage, Marianne, MD, PhD, Wahlgren, Carl-Fredrik, MD, PhD
Format: Article
Language:English
Subjects:
Age
Allergy and Immunology
Animals
Biological and medical sciences
Breastfeeding & lactation
Cats
Child
Child, Preschool
Eczema
Eczema - epidemiology
Eczema - genetics
Eczema - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunopathology
Infant
Intermediate Filament Proteins - genetics
Medical sciences
Medicin och hälsovetenskap
Mutation
Population
Prevalence
Questionnaires
Risk
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Siblings
Skin - immunology
Skin - pathology
Skin Diseases - genetics
Skin Diseases - immunology
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Summary:Proportions and odds ratios (ORs) are shown with 95% CIs. [...]tests for gene-environment interactions were performed between FLG mutations and presence of siblings or cat in the household at birth according to the information provided in the questionnaires. [...]our prospective study shows that FLG mutations increase the risk for persistent dry skin, persistent eczema, and AE and non-AE at age 8 years, without interactions between FLG mutations and siblings or cat in the household at birth.
ISSN:0091-6749
1097-6825
1097-6825
DOI:10.1016/j.jaci.2011.11.032