Human ROBO1 regulates interaural interaction in auditory pathways

In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional...

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Bibliographic Details
Published in:The Journal of neuroscience 2012-01, Vol.32 (3), p.966-971
Main Authors: Lamminmäki, Satu, Massinen, Satu, Nopola-Hemmi, Jaana, Kere, Juha, Hari, Riitta
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Adult
Analysis of Variance
Auditory Cortex - physiopathology
Auditory Pathways - physiopathology
DNA Mutational Analysis
Dyslexia - genetics
Dyslexia - pathology
Dyslexia - physiopathology
Ear - physiopathology
Electroencephalography
Evoked Potentials, Auditory - genetics
Family Health
Female
Functional Laterality - genetics
Gene Expression Regulation - genetics
Humans
Magnetic Resonance Imaging
Magnetoencephalography
Male
Middle Aged
Nerve Tissue Proteins - genetics
Reaction Time - genetics
Receptors, Immunologic - genetics
Roundabout Proteins
Young Adult
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Summary:In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dose-dependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.4007-11.2012