Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5

Highlights ► Inter-species divergence between P. falciparum and P. reichenowi is comparable to housekeeping genes. ► A signature of purifying selection was detected in the proenzyme and enzyme domains. ► No strong evidence for positive selection was detected for SNPs in the non-repeat regions. ► Bia...

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Bibliographic Details
Published in:Vaccine 2012-02, Vol.30 (9), p.1583-1593
Main Authors: Tanabe, Kazuyuki, Arisue, Nobuko, Palacpac, Nirianne M.Q, Yagi, Masanori, Tougan, Takahiro, Honma, Hajime, Ferreira, Marcelo U, Färnert, Anna, Björkman, Anders, Kaneko, Akira, Nakamura, Masatoshi, Hirayama, Kenji, Mita, Toshihiro, Horii, Toshihiro
Format: Article
Language:English
Subjects:
Africa
Allergy and Immunology
Amino Acid Sequence
amino acid sequences
antibodies
antigens
Antigens, Protozoan - genetics
Asia, Southeastern
blood serum
DNA, Protozoan - genetics
gene flow
Gene Frequency
genes
genetic techniques and protocols
genetic variation
Genetics, Population
Geographical differentiation
geographical distribution
Geography
Haplotypes
humans
Malaria
merozoites
Molecular Sequence Data
Oceania
Pan troglodytes
parasites
Plasmodium falciparum
Plasmodium falciparum - genetics
Plasmodium reichenowi
Polymorphism
Polymorphism, Single Nucleotide
proteinases
Selection, Genetic
Sequence Analysis, DNA
SERA5
serine
single nucleotide polymorphism
South America
Species Specificity
Vaccine
vaccines
variance
virulence
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Description
Summary:Highlights ► Inter-species divergence between P. falciparum and P. reichenowi is comparable to housekeeping genes. ► A signature of purifying selection was detected in the proenzyme and enzyme domains. ► No strong evidence for positive selection was detected for SNPs in the non-repeat regions. ► Biased geographical distribution was observed in SNPs and in the haplotypes of the OR and SR regions. ► Significant genetic differentiation was detected for SNPs and OR- and SR-haplotypes among parasite populations.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.12.124