p47 phox Is Required for Afferent Arteriolar Contractile Responses to Angiotensin II and Perfusion Pressure in Mice

Myogenic and angiotensin contractions of afferent arterioles generate reactive oxygen species. Resistance vessels express neutrophil oxidase-2 and -4. Angiotensin II activates p47 phox /neutrophil oxidase-2, whereas it downregulates NOX-4. Therefore, we tested the hypothesis that p47 phox enhances a...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2012-02, Vol.59 (2), p.415-420
Main Authors: Lai, En Yin, Solis, Glenn, Luo, Zaiming, Carlstrom, Mattias, Sandberg, Kathryn, Holland, Steven, Wellstein, Anton, Welch, William J., Wilcox, Christopher S.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Myogenic and angiotensin contractions of afferent arterioles generate reactive oxygen species. Resistance vessels express neutrophil oxidase-2 and -4. Angiotensin II activates p47 phox /neutrophil oxidase-2, whereas it downregulates NOX-4. Therefore, we tested the hypothesis that p47 phox enhances afferent arteriolar angiotensin contractions. Angiotensin II infusion in p47 phox +/+ but not −/− mice increased renal cortical NADPH oxidase activity (7±1–12±1 [ P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.111.184291