Negative Emotions and Cytokines in Maternal and Cord Serum at Preterm Birth

Problem  This study investigates whether affectivity differs between mothers delivering preterm and term and whether maternal and umbilical cord serum cytokines differ between these groups. Further, whether there are associations between mothers’ emotions and maternal and cord cytokines at preterm a...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2012-06, Vol.67 (6), p.506-514
Main Authors: Fransson, Emma, Dubicke, Aurelija, Byström, Birgitta, Ekman-Ordeberg, Gunvor, Hjelmstedt, Anna, Lekander, Mats
Format: Article
Language:English
Subjects:
Adult
Cord blood
cytokines
Cytokines - blood
depression
Depression - blood
Depression - immunology
Depression - psychology
Emotions
Female
Fetal Blood - immunology
Humans
Male
Medicin och hälsovetenskap
neonatal immune function
Pregnancy
premature birth
Premature Birth - blood
Premature Birth - immunology
Premature Birth - psychology
psychoneuroimmunology
Young Adult
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Summary:Problem  This study investigates whether affectivity differs between mothers delivering preterm and term and whether maternal and umbilical cord serum cytokines differ between these groups. Further, whether there are associations between mothers’ emotions and maternal and cord cytokines at preterm and term birth. Method of study  Twenty‐seven mothers delivering preterm and 37 mothers delivering at term reported positive/negative affect and previous depressive symptoms during pregnancy. Blood samples from mothers in labor and cord samples (23 preterm and 33 term) were analyzed for cytokines. Results  Maternal IL‐8 was lower at preterm delivery compared with term. In the preterm group only, associations were found between negative emotions and maternal IL‐6, IL‐8 and cord IL‐6, IL‐8, IL‐10, IL‐13, and IL‐18. Conclusion  The findings indicate associations in preterm delivery between negative emotions and both maternal and neonate immune activity. Future studies should investigate whether such associations are part of the etiology of preterm delivery.
ISSN:1046-7408
8755-8920
1600-0897
1600-0897
DOI:10.1111/j.1600-0897.2011.01081.x