Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA: a pilot study

• Published in: European radiology 2012-03, Vol.22 (3), p.642-653
• Main Authors: Dahlqvist Leinhard, O., Dahlström, N., Kihlberg, J., Sandström, P., Brismar, T. B., Smedby, Ö., Lundberg, P.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Contrast agents; Contrast Media; Contrast Media - pharmacokinetics; Councils; Diagnostic Radiology; Female; Gadolinium DTPA - pharmacokinetics; Gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid – Gadobenate Dimeglumine – Dynamic contrast-enhanced MRI – Pharmacokinetics – Liver; Humans; Image Interpretation, Computer-Assisted; Imaging; Internal Medicine; Interventional Radiology; Liver; Liver - metabolism; Liver Diseases - diagnosis; Liver Diseases - metabolism; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Meglumine - analogs & derivatives; Meglumine - pharmacokinetics; Middle Aged; Neuroradiology; Organometallic Compounds - pharmacokinetics; Patients; Pharmacokinetics; Pilot Projects; Prospective Studies; Radiation; Radiology; Retrospective Studies; Spleen - metabolism; Surgery; Treatment Outcome; Ultrasound
• ISSN: 0938-7994; 1432-1084; 1432-1084
• DOI: 10.1007/s00330-011-2302-4

Objectives To develop and evaluate a procedure for quantifying the hepatocyte-specific uptake of Gd-BOPTA and Gd-EOB-DTPA using dynamic contrast-enhanced (DCE) MRI. Methods Ten healthy volunteers were prospectively recruited and 21 patients with suspected hepatobiliary disease were retrospectively evaluated. All subjects were examined with DCE-MRI using 0.025 mmol/kg of Gd-EOB-DTPA. The healthy volunteers underwent an additional examination using 0.05 mmol/kg of Gd-BOPTA. The signal intensities (SI) of liver and spleen parenchyma were obtained from unenhanced and enhanced acquisitions. Using pharmacokinetic models of the liver and spleen, and an SI rescaling procedure, a hepatic uptake rate, K Hep , estimate was derived. The K Hep values for Gd-EOB-DTPA were then studied in relation to those for Gd-BOPTA and to a clinical classification of the patient’s hepatobiliary dysfunction. Results K Hep estimated using Gd-EOB-DTPA showed a significant Pearson correlation with K Hep estimated using Gd-BOPTA ( r  = 0.64; P