Long term perturbation of endocrine parameters and cholesterol metabolism after discontinued abuse of anabolic androgenic steroids

• Published in: The Journal of steroid biochemistry and molecular biology 2011-11, Vol.127 (3), p.295-300
• Main Authors: Gårevik, Nina, Strahm, Emmanuel, Garle, Mats, Lundmark, Jonas, Ståhle, Lars, Ekström, Lena, Rane, Anders
• Format: Article
• Language: English
• Subjects: Anabolic Agents - administration & dosage; Anabolic androgenic steroids; Androgens - administration & dosage; Biological and medical sciences; Biomarkers - metabolism; Cholesterol - metabolism; Follicle Stimulating Hormone - blood; Fundamental and applied biological sciences. Psychology; Glucuronosyltransferase - genetics; Humans; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Luteinizing Hormone - blood; Medicin och hälsovetenskap; Minor Histocompatibility Antigens; Nandrolone; T/E; Testosterone; Vertebrates: endocrinology; Vertebrates: reproduction
• ISSN: 0960-0760; 1879-1220; 1879-1220
• DOI: 10.1016/j.jsbmb.2011.08.005

► 1 year follow-up study in androgenic anabolic steroids abusers. ► Compromised hypothalamic–pituitary–adrenal axis in all volunteers. ► Main urinary nandrolone metabolite is detected up to 12 months after abuse cessation. ► HDL increased and LDL decreased observed until 6 month after abuse cessation. ► Long term consequences might be expected. To study the long-term impact of anabolic androgenic steroid (AAS) abuse on the cholesterol profile, and the potential to suppress endocrine activity in men working out at gym facilities. To study the relation between urinary biomarkers for testosterone and nandrolone abuse and the UGT2B17 genotype and time profile. Subjects ( N = 56) were recruited through Anti-Doping Hot-Line. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), plasma levels of low density lipoprotein (LDL), high density lipoprotein (HDL) and urinary steroid profile were regularly measured for a period of up to one year after cessation of intramuscular AAS abuse. A sustained suppression of LH, and FSH was observed for several months. The nandrolone urinary biomarker 19-NA was detectable several months after the last nandrolone intake and was correlated to the levels of LH and FSH. Testosterone abuse on the other hand was detectable only for a few weeks, and some of the testosterone abusers did not test positive due to a genetic deletion polymorphism of the UGT2B17. Significantly increased levels of HDL and decreased levels of LDL were observed for 6-months after cessation of AAS abuse. Some individuals had a sustained suppression of LH and FSH for a period of 1 year whereas the cholesterol profile was normalized within 6 month. The long term consequences of these findings remain to be established.