Four and five dimensional radiotherapy with reference to prostate cancer - definitions, state of the art and further directions - an overview

Abstract Radiotherapy (RT) always requires a compromise between tumor control and normal tissue side-effects. Technical innovation in radiation therapy (RT), such as three dimensional RT, is now established. Concerning prostate cancer (PC), it is reasonable to assume that RT of PC will increase in t...

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Bibliographic Details
Published in:Acta oncologica 2011-06, Vol.50 (S1), p.104-110
Main Authors: Lennernäs, Bo, CastellanoS, Enrique, Nilsson, Sten, Levitt, Seymour
Format: Article
Language:English
Subjects:
Brachytherapy
Cancer and Oncology
Cancer och onkologi
Diagnostic Imaging
Humans
Imaging, Three-Dimensional
Male
Medicin och hälsovetenskap
Prognosis
Prostatic Neoplasms - radiotherapy
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated
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Summary:Abstract Radiotherapy (RT) always requires a compromise between tumor control and normal tissue side-effects. Technical innovation in radiation therapy (RT), such as three dimensional RT, is now established. Concerning prostate cancer (PC), it is reasonable to assume that RT of PC will increase in the future. The combination of small margins, a movable target (prostate), few fractions and high doses will probably demand dynamically positioning systems and in real time. This is called four dimensional radiotherapy (4DRT). Moreover, biological factors must be included in new treatments such as hypofractionation schedules. This new era is called five dimensional radiotherapy, 5DRT. In this paper we discuss new concepts in RT in respect to PC.
ISSN:0284-186X
1651-226X
1651-226X
DOI:10.3109/0284186X.2010.530003