Placental IGF-I, IGFBP-1, zinc, and iron, and maternal and infant anthropometry at birth

• Published in: Acta Paediatrica 2011-11, Vol.100 (11), p.1504-1509
• Main Authors: Akram, Shahzad K, Carlsson-Skwirut, Christine, Bhutta, Zulfiqar A, Söder, Olle
• Format: Article
• Language: English
• Subjects: Anthropometry; Biological and medical sciences; Diseases of mother, fetus and pregnancy; Female; General aspects; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn; Infant, Small for Gestational Age - metabolism; Insulin; Insulin-Like Growth Factor Binding Protein 1 - metabolism; Insulin-like growth factor binding protein-1; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factor-1; Insulin-like growth factors; Iron; Iron, Dietary - metabolism; Large for gestational age; Medical sciences; Medicin och hälsovetenskap; Mothers - statistics & numerical data; Pakistan; Placenta - chemistry; Placenta - metabolism; Pregnancy; Pregnancy. Fetus. Placenta; Proteins; Small for gestational age; Zinc; Zinc - metabolism
• ISSN: 0803-5253; 1651-2227; 1651-2227
• DOI: 10.1111/j.1651-2227.2011.02336.x

Aim:  To correlate placental protein levels of insulin‐like growth factor (IGF)‐I and insulin‐like growth factor binding protein (IGFBP)‐1, with previously determined levels of IGF‐I and IGF‐II mRNA expression, and the micronutrients zinc and iron, and maternal and newborn anthropometry. Methods:  Placental samples were collected from rural field sites in Pakistan. Samples were divided into small and large for gestational age groups (SGA and LGA, respectively). IGFBP‐1 levels were assessed using Western immunoblotting. IGF‐I protein levels were assessed using ELISA techniques. IGF mRNA expression, zinc, and iron, were quantified as previously described and were used for comparative purposes only. Results:  Thirty‐three subjects were included (SGA, n = 12; LGA n = 21). Higher levels of IGFBP‐1 were seen in the SGA group (p