Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies

• Published in: Diabetologia 2011-05, Vol.54 (5), p.1013-1018
• Main Authors: Larsson, S. C., Wolk, A.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Body mass index; Child; Child, Preschool; Cigarettes; Cohort analysis; Diabetes; Diabetes Mellitus - epidemiology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiology; Estimates; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Human Physiology; Humans; Infant; Infant, Newborn; Internal Medicine; Kidney cancer; Kidney Neoplasms - epidemiology; Kidneys; Male; Medical sciences; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Meta-analysis; Metabolic Diseases; Middle Aged; Mortality; Nephrology. Urinary tract diseases; Obesity; Risk Factors; Smoking; Tumors of the urinary system; Young Adult
• ISSN: 0012-186X; 1432-0428; 1432-0428
• DOI: 10.1007/s00125-011-2051-6

Aims/hypothesis Diabetes is associated with increased risk of cancer at several sites, but its association with cancer of the kidney is unclear. We performed a systematic review with meta-analysis to examine the association between diabetes and incidence of kidney cancer. Methods Pertinent studies were identified by searching PubMed (from January 1966 to December 2010) and reviewing the reference lists of relevant articles. We included cohort studies reporting RR estimates and 95% CI (or data to calculate them) of the association between diabetes and kidney cancer incidence. Summary RRs were calculated using a random-effects model. Results Nine cohort studies met the inclusion criteria. Analysis of all studies showed that compared with individuals without diabetes, patients with diabetes had a statistically significant increased risk of kidney cancer (RR 1.42, 95% CI 1.06–1.91). There was heterogeneity among studies ( p