Genomic and genetic alterations influence the progression of gastric cancer

Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed i...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2011-01, Vol.17 (3), p.290-299
Main Authors: Nobili, Stefania, Bruno, Lorenzo, Landini, Ida, Napoli, Cristina, Bechi, Paolo, Tonelli, Francesco, Rubio, Carlos A, Mini, Enrico, Nesi, Gabriella
Format: Article
Language:English
Subjects:
Disease Progression
DNA Methylation
Epigenomics
Genome, Human
Genomic Instability
Humans
Loss of Heterozygosity
Microsatellite Repeats
Mutation
Review
Signal Transduction - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - physiopathology
发病率
基因变异
基因改变
基因组
微卫星不稳定性
表观遗传
西方国家
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Summary:Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity （LOH）, microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric cancer.In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v17.i3.290