Non-invasive monitoring of blood haemoglobin for analysis of fluid volume kinetics

Background: A commercially available pulse oximeter that reports blood haemoglobin (Hb) concentration is evaluated. This study considers whether this device can provide serial Hb data that would be sufficiently reliable for volume kinetic analysis of infusion fluids. Methods: Forty infusions of 5 or...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2010-11, Vol.54 (10), p.1233-1240
Main Authors: HAHN, R. G., LI, Y., ZDOLSEK, J.
Format: Article
Language:English
Subjects:
Adult
Algorithms
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Volume - physiology
Female
Fluid Therapy
Hematocrit
Hemoglobins - analysis
Humans
Infusions, Intravenous
Isotonic Solutions - therapeutic use
Kinetics
Male
Medical sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Monitoring, Intraoperative
Oximetry - instrumentation
Oximetry - methods
Plasma Substitutes - therapeutic use
Regional Blood Flow - physiology
Regression Analysis
Young Adult
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Summary:Background: A commercially available pulse oximeter that reports blood haemoglobin (Hb) concentration is evaluated. This study considers whether this device can provide serial Hb data that would be sufficiently reliable for volume kinetic analysis of infusion fluids. Methods: Forty infusions of 5 or 10 ml/kg of acetated Ringer's solution were given over 15 min in 10 healthy volunteers. Hb was measured on 17 different occasions over 120 min using the Radical 7 pulse oximeter and compared with the result of invasive blood sampling (control). A one‐volume kinetic model was applied to each data series. The pulse oximeter also reported the perfusion index (PI). Results: The median deviation between the 680 invasive and non‐invasive Hb samples (the accuracy) was 1.6% and the absolute median deviation (precision) was 4.6%. Between‐subject factors explained half of the variation in the difference between non‐invasive vs. invasive sampling. Ten of the 40 non‐invasive series of Hb values were discarded from kinetic analysis due to poor quality. The remaining 30 series showed a smaller distribution volume for the infused fluid when kinetic analysis was based on the non‐invasive method (3.0 vs. 5.3 l; P
ISSN:0001-5172
1399-6576
1399-6576
DOI:10.1111/j.1399-6576.2010.02321.x