In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

Abstract Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD

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Bibliographic Details
Published in:Leukemia research 2011-04, Vol.35 (4), p.472-478
Main Authors: Lönnerholm, Gudmar, Thörn, Ingrid, Sundström, Christer, Frost, Britt-Marie, Flaegstad, Trond, Heyman, Mats, Jonsson, Olafur Gisli, Harila-Saari, Arja, Madsen, Hans O, Porwit, Anna, Schmiegelow, Kjeld, Söderhäll, Stefan, Wesenberg, Finn, Vettenranta, Kim, Larsson, Rolf, Forestier, Erik
Format: Article
Language:English
Subjects:
acute lymphoblastic leukemia
Adolescent
Antineoplastic Agents - pharmacology
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bone Marrow Cells - drug effects
Bone Marrow Cells - metabolism
Bone Marrow Cells - pathology
Child
Child, Preschool
childhood
Chromosome Aberrations
Doxorubicin - pharmacology
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Female
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Humans
in vitro drug resistance
Infant
Male
MEDICIN
Medicin och hälsovetenskap
MEDICINE
MRD
Neoplasm, Residual - diagnosis
Neoplasm, Residual - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Prednisolone - pharmacology
Prognosis
prognostic factors
Risk Factors
Vincristine - pharmacology
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Description
Summary:Abstract Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD
ISSN:0145-2126
1873-5835
1873-5835
DOI:10.1016/j.leukres.2010.09.001