Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. Oligodendrocyte...

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Bibliographic Details
Published in:Cell stem cell 2010-10, Vol.7 (4), p.470-482
Main Authors: Barnabé-Heider, Fanie, Göritz, Christian, Sabelström, Hanna, Takebayashi, Hirohide, Pfrieger, Frank W., Meletis, Konstantinos, Frisén, Jonas
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Fundamental and applied biological sciences. Psychology
Human health and pathology
Immunohistochemistry
Life Sciences
Medicin och hälsovetenskap
Mice
Mice, Transgenic
Molecular and cellular biology
Neuroglia - cytology
Spinal Cord Injuries
Spinal Cord Regeneration
Stem Cells - cytology
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Summary:Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. Oligodendrocyte progenitors self-renew, give rise to new mature oligodendrocytes, and constitute the dominating proliferating cell population in the intact adult spinal cord. In contrast, astrocytes and ependymal cells, which are restricted to limited self-duplication in the intact spinal cord, generate the largest number of cells after spinal cord injury. Only ependymal cells generate progeny of multiple fates, and neural stem cell activity in the intact and injured adult spinal cord is confined to this cell population. We provide an integrated view of how several distinct cell types contribute in complementary ways to cell maintenance and the reaction to injury. [Display omitted] ► Oligodendrocyte progenitors continuously make oligodendrocytes in the adult spinal cord ► Ependymal cells contribute to remyelination after injury ► Astrocytes and ependymal cells generate the glial scar after spinal cord injury ► Neural stem cell properties are restricted to the ependymal cell population
ISSN:1934-5909
1875-9777
1875-9777
DOI:10.1016/j.stem.2010.07.014