Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk

Summary A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore...

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Bibliographic Details
Published in:British journal of haematology 2010-08, Vol.150 (4), p.473-479
Main Authors: Crowther‐Swanepoel, Dalemari, Mansouri, Mahmoud, Enjuanes, Anna, Vega, Ana, Smedby, Karin E., Ruiz‐Ponte, Clara, Jurlander, Jesper, Juliusson, Gunnar, Montserrat, Emilio, Catovsky, Daniel, Campo, Elias, Carracedo, Angel, Rosenquist, Richard, Houlston, Richard S.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Case-Control Studies
Chromosome Aberrations
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 15 - genetics
Chromosomes, Human, Pair 19 - genetics
Chromosomes, Human, Pair 2 - genetics
Chromosomes, Human, Pair 6 - genetics
chronic lymphocytic leukaemia
Clinical Medicine
Female
Gene Frequency
Genetic Predisposition to Disease
genome wide association
Genome-Wide Association Study
Genotype
Hematologi
Hematologic and hematopoietic diseases
Hematology
Humans
Klinisk medicin
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical and Health Sciences
Medical sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Middle Aged
Polymorphism, Single Nucleotide
risk
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Summary:Summary A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case‐control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (Ptrend = 1·40 × 10−15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.
ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/j.1365-2141.2010.08270.x