Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

Apoptosis might proceed through the activation of both caspase-dependent and -independent pathways. Apoptosis-inducing factor (AIF) was discovered as the first protein that mediated caspase-independent cell death. Initially, it was regarded as a soluble protein residing in the intermembrane space of...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2010-05, Vol.396 (1), p.95-100
Main Authors: Norberg, Erik, Orrenius, Sten, Zhivotovsky, Boris
Format: Article
Language:English
Subjects:
AIF
Animals
Apoptosis
Apoptosis Inducing Factor - genetics
Apoptosis Inducing Factor - metabolism
Calcium - metabolism
Calpain
Cathepsin
Humans
Medicin och hälsovetenskap
Mice
Mitochondria
Mitochondria - enzymology
Reactive oxygen species (ROS)
Reactive Oxygen Species - metabolism
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Summary:Apoptosis might proceed through the activation of both caspase-dependent and -independent pathways. Apoptosis-inducing factor (AIF) was discovered as the first protein that mediated caspase-independent cell death. Initially, it was regarded as a soluble protein residing in the intermembrane space of mitochondria, from where it could be exported to the nucleus to participate in large-scale DNA fragmentation and chromatin condensation. However, later it was demonstrated that AIF is N-terminally anchored to the inner mitochondrial membrane. Hence, AIF must be liberated from its membrane anchor prior to being released into the cytosol. The current knowledge about the molecular mechanisms regulating the processing and release of AIF from the mitochondria will be summarized and discussed in this review.
ISSN:0006-291X
1090-2104
1090-2104
DOI:10.1016/j.bbrc.2010.02.163