GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role

Psoriasis is a chronic inflammatory disease in which pruritus is a common symptom. Pruritus may be associated with the gamma-aminobutyric acid (GABA) system. The distribution of GABA and its GABA(A) receptor (R) was studied in involved and non-involved psoriatic skin, as well as normal healthy contr...

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Bibliographic Details
Published in:ARCHIVES OF DERMATOLOGICAL RESEARCH 2010-09, Vol.302 (7), p.507-515
Main Authors: Nigam, Rishi, El-Nour, Husameldin, Amatya, Beni, Nordlind, Klas
Format: Article
Language:English
Subjects:
Adult
Aged
Female
gamma-Aminobutyric Acid - metabolism
Humans
Immunohistochemistry
Lymphocytes - immunology
Lymphocytes - metabolism
Lymphocytes - pathology
Macrophages - immunology
Macrophages - metabolism
Macrophages - pathology
Male
Medicin och hälsovetenskap
Middle Aged
Neutrophils - immunology
Neutrophils - metabolism
Neutrophils - pathology
Pain Measurement
Pruritus
Psoriasis - immunology
Psoriasis - pathology
Psoriasis - physiopathology
Receptors, GABA-A - metabolism
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Summary:Psoriasis is a chronic inflammatory disease in which pruritus is a common symptom. Pruritus may be associated with the gamma-aminobutyric acid (GABA) system. The distribution of GABA and its GABA(A) receptor (R) was studied in involved and non-involved psoriatic skin, as well as normal healthy control skin, using an immunohistochemistry technique. Pruritus was determined using a visual analog scale. Inflammatory cells immunoreactive for the GABA ligand and the GABA(A) R were increased (P < 0.01, respectively) in the involved skin. Cells stained for GABA ligand were mostly macrophages with some lymphocytes, while cells stained for GABA(A) R were macrophages, neutrophils or lymphocytes. There was a positive correlation when comparing GABA ligand (P = 0.05) and GABA(A) R (P < 0.05) expressing inflammatory cells, with pruritus. The GABA ligand and its GABA(A) R may play a role for the pathogenesis of psoriasis as well as for pruritus in this disease.
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-010-1052-5