Dose-related effects of red wine and alcohol on heart rate variability

In healthy subjects a standard drink of either red wine (RW) or ethanol (EtOH) has no effect on muscle sympathetic nerve activity or on heart rate (HR), whereas two drinks increase both. Using time- and frequency-domain indexes of HR variability (HRV), we now tested in 12 subjects (24-47 yr, 6 men)...

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Published in:American journal of physiology. Heart and circulatory physiology 2010-06, Vol.298 (6), p.H2226-H2231
Main Authors: Spaak, Jonas, Tomlinson, George, McGowan, Cheri L, Soleas, George J, Morris, Beverley L, Picton, Peter, Notarius, Catherine F, Floras, John S
Format: Article
Language:English
Subjects:
Adult
Alcohol
Comparative analysis
Dose-Response Relationship, Drug
Drinking water
Effects
Ethanol - pharmacology
Female
Heart - innervation
Heart - physiology
Heart rate
Heart Rate - drug effects
Heart Rate - physiology
Humans
Hypothesis testing
Male
Medicin och hälsovetenskap
Middle Aged
Single-Blind Method
Spectrum analysis
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiology
Wine
Wines
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Summary:In healthy subjects a standard drink of either red wine (RW) or ethanol (EtOH) has no effect on muscle sympathetic nerve activity or on heart rate (HR), whereas two drinks increase both. Using time- and frequency-domain indexes of HR variability (HRV), we now tested in 12 subjects (24-47 yr, 6 men) the hypotheses that 1) this HR increase reflects concurrent dose-related augmented sympathetic HR modulation and 2) RW with high-polyphenol content differs from EtOH in its acute HRV effects. RW, EtOH, and water were provided on 3 days, 2 wk apart according to a randomized, single-blind design. Eight-minute segments were analyzed. One alcoholic drink increased blood concentrations to 36 + or - 2 mg/dl (mean + or - SE), and 2 drinks to 72 + or - 4 (RW) and 80 + or - 2 mg/dl (EtOH). RW quadrupled plasma resveratrol (P < 0.001). HR fell after both water drinks. When compared with respective baselines, one alcoholic drink had no effect on HR or HRV, whereas two glasses of both increased HR (RW, +5.4 + or - 1.2; and EtOH, +5.7 + or - 1.2 min(-1); P < 0.001), decreased total HRV by 28-33% (P < 0.05) and high-frequency spectral power by 32-42% (vagal HR modulation), and increased low-frequency power by 28-34% and the ratio of low frequency to high frequency by 98-119% (sympathetic HR modulation) (all, P < or = 0.01). In summary, when compared with water, one standard drink lowered time- and frequency-domain markers of vagal HR modulation. When compared with respective baselines, two alcoholic drinks increased HR by diminished vagal and augmented sympathetic HR modulation. Thus alcohol exerts dose-dependent HRV responses, with RW and EtOH having a similar effect.
ISSN:0363-6135
1522-1539
1522-1539
DOI:10.1152/ajpheart.00700.2009