Cell death mechanisms: Cross-talk and role in disease

Multiple cell death mechanisms operate in both uni- and multicellular organisms. Hence, research during the past forty years has revealed that apoptosis is not the only cell death program involved in the regulation of tissue homeostasis and the removal of unwanted cells in biological organisms. Whil...

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Bibliographic Details
Published in:Experimental cell research 2010-05, Vol.316 (8), p.1374-1383
Main Authors: Zhivotovsky, Boris, Orrenius, Sten
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cancer
Cell death
Cell Death - physiology
Cellular biology
Cross-talk
Disease
Humans
Medicin och hälsovetenskap
Mitochondria
Molecular biology
Neurological disorders
Signal Transduction
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Summary:Multiple cell death mechanisms operate in both uni- and multicellular organisms. Hence, research during the past forty years has revealed that apoptosis is not the only cell death program involved in the regulation of tissue homeostasis and the removal of unwanted cells in biological organisms. While the molecular pathways of apoptosis and necrosis are now relatively well established, the precise mechanisms of other cell death modalities, and their cross-talk, require additional study. This is particularly important, since many human disorders can be attributed, directly or indirectly, to defective cell death mechanisms. In this review we shall discuss the characteristics and cross-talk between various modes of cell death and their role in cell death-related disorders, notably, neurodegenerative disease and cancer.
ISSN:0014-4827
1090-2422
1090-2422
DOI:10.1016/j.yexcr.2010.02.037