Massive Fundic Gland Polyposis in a Patient Receiving Protracted Proton-Pump Inhibitor Medication

A case of massive fundic gland polyposis (MFGPsis) in a female patient receiving protracted proton-pump inhibitor (PPI) medication is described. At gross examination the majority of the polyps were overlapping, confluent, some of them having a “cauliflower-like” configuration. The fundic gland p...

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Bibliographic Details
Published in:Anticancer research 2010-01, Vol.30 (1), p.261-264
Main Authors: Rubio, Carlos A, Befrits, Ragnar, Osterberg, Johanna, Ohd, John, Miller, Marian L, Ramel, Stig
Format: Article
Language:English
Subjects:
Biological and medical sciences
Female
Gastric Fundus - drug effects
Gastric Fundus - pathology
Humans
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Polyps - chemically induced
Polyps - pathology
Proton Pump Inhibitors - adverse effects
Stomach Diseases - chemically induced
Stomach Diseases - pathology
Tumors
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Summary:A case of massive fundic gland polyposis (MFGPsis) in a female patient receiving protracted proton-pump inhibitor (PPI) medication is described. At gross examination the majority of the polyps were overlapping, confluent, some of them having a “cauliflower-like” configuration. The fundic gland polyps (FGP) arose in the gastric acid secretory mucosa. The confluence of these polyps impeded their enumeration. The gross and histological characteristics of this case seemed to be at variance with syndromic or sporadic cases having multiple FGP, inasmuch as in this case, the FGP had a propensity to agglutinate, to overlap and to develop confluent macrocysts. Another difference was that this disease, refractory to antacid treatment, required surgical intervention. This case substantiates the notion that protracted PPI medication may encourage the development of MFGPsis in susceptible individuals.
ISSN:0250-7005
1791-7530
1791-7530