Age-related changes of muscle and plasma amino acids in healthy children

The aim of the study was to explore if changes in muscle and plasma amino acid concentrations developed during growth and differed from levels seen in adults. The gradient and concentrations of free amino acids in muscle and plasma were investigated in relation to age in metabolic healthy children....

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Bibliographic Details
Published in:Amino acids 2010-07, Vol.39 (2), p.359-366
Main Authors: Hammarqvist, Folke, Angsten, Gertrud, Meurling, Staffan, Andersson, Kerstin, Wernerman, Jan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aging
Amino acids
Amino Acids - blood
Amino Acids - metabolism
Amino Acids, Branched-Chain - metabolism
Amino Acids, Essential - metabolism
Analytical Chemistry
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Child
Child Development - physiology
Child, Preschool
Children & youth
Growth
Humans
Infant
Life Sciences
Male
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Muscle, Skeletal - metabolism
Neurobiology
Original Article
Plasma
Proteomics
Skeletal muscle
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Summary:The aim of the study was to explore if changes in muscle and plasma amino acid concentrations developed during growth and differed from levels seen in adults. The gradient and concentrations of free amino acids in muscle and plasma were investigated in relation to age in metabolic healthy children. Plasma and specimens from the abdominal muscle were obtained during elective surgery. The children were grouped into three groups (group 1: < 1 year, n = 8; group 2: 1-4 years, n = 13 and group 3: 5-15 years, n = 15). A reference group of healthy adults (21-38 years, n = 22) was included in their comparisons and reflected specific differences between children and adults. In muscle the concentrations of 8 out of 19 amino acids analysed increased with age, namely taurine, aspartate, threonine, alanine, valine, isoleucine, leucine, histidine, as well as the total sums of branched chain amino acids (BCAA), basic amino acids (BAA) and total sum of amino acids (P < 0.05). In plasma the concentrations of threonine, glutamine, valine, cysteine, methionine, leucine, lysine, tryptophane, arginine, BCAA, BAA and the essential amino acids correlated with age (P < 0.05). These results indicate that there is an age dependency of the amino acid pattern in skeletal muscle and plasma during growth.
ISSN:0939-4451
1438-2199
1438-2199
DOI:10.1007/s00726-009-0446-1