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Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma
Background Tumor necrosis factor (TNF) and interleukin 10 (IL10) are promising candidate susceptibility genes for non-Hodgkin lymphoma (NHL). Chromosomal translocation breakpoint genes are of interest, given their documented involvement in lymphoma progression. Methods We analyzed 11 polymorphisms i...
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| Published in: | Cancer causes & control 2010-05, Vol.21 (5), p.759-769 |
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| creator | Fernberg, Pia Chang, Ellen T Duvefelt, Kristina Hjalgrim, Henrik Eloranta, Sandra Sørensen, Karina Meden Porwit, Anna Humphreys, Keith Melbye, Mads Ekström Smedby, Karin |
| description | Background Tumor necrosis factor (TNF) and interleukin 10 (IL10) are promising candidate susceptibility genes for non-Hodgkin lymphoma (NHL). Chromosomal translocation breakpoint genes are of interest, given their documented involvement in lymphoma progression. Methods We analyzed 11 polymorphisms in BCL2, CCND1, MYC, TNF, and IL10 in a large, population-based, Danish-Swedish case-control study including 2,449 NHL cases and 1,980 controls. Relative risk of NHL was computed as odds ratios (OR). Results There was no clear evidence of associations between variants in BCL2, CCND1, and MYC and risk of NHL overall or subtypes. TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for minor allele homozygosity), T-cell lymphoma (OR 2.54, CI 1.27-5.09) and mantle cell lymphoma (OR 2.84, CI 1.38-5.87). IL10 rs1800890 was associated with risk of diffuse large B-cell lymphoma (OR 1.41, CI 1.08-1.85 for minor allele homozygosity) and mantle cell lymphoma (OR 1.77, CI 1.04-3.00). We did not replicate a previously reported interaction with autoimmunity. Conclusions We found no support for a role of the studied variants in BCL2, CCND1, or MYC in risk of NHL or subtypes, but we provide further evidence of putative susceptibility loci in TNF and IL10 for specific NHL subtypes. |
| doi_str_mv | 10.1007/s10552-010-9504-y |
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Chromosomal translocation breakpoint genes are of interest, given their documented involvement in lymphoma progression. Methods We analyzed 11 polymorphisms in BCL2, CCND1, MYC, TNF, and IL10 in a large, population-based, Danish-Swedish case-control study including 2,449 NHL cases and 1,980 controls. Relative risk of NHL was computed as odds ratios (OR). Results There was no clear evidence of associations between variants in BCL2, CCND1, and MYC and risk of NHL overall or subtypes. TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for minor allele homozygosity), T-cell lymphoma (OR 2.54, CI 1.27-5.09) and mantle cell lymphoma (OR 2.84, CI 1.38-5.87). IL10 rs1800890 was associated with risk of diffuse large B-cell lymphoma (OR 1.41, CI 1.08-1.85 for minor allele homozygosity) and mantle cell lymphoma (OR 1.77, CI 1.04-3.00). We did not replicate a previously reported interaction with autoimmunity. Conclusions We found no support for a role of the studied variants in BCL2, CCND1, or MYC in risk of NHL or subtypes, but we provide further evidence of putative susceptibility loci in TNF and IL10 for specific NHL subtypes.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-010-9504-y</identifier><identifier>PMID: 20087644</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Adolescent ; Adult ; Aged ; Autoimmune diseases ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Cancer ; Cancer Research ; Case-Control Studies ; Cell cycle ; Cyclin D1 - genetics ; Cytokines ; DNA ; Epidemiology ; Female ; Genes ; Genes, bcl-2 - genetics ; Genes, myc - genetics ; Genetic variation ; Genomics ; Genotypes ; Hardy Weinberg law ; Hematology ; HIV ; Human immunodeficiency virus ; Humans ; Infections ; Interleukin-10 - genetics ; Interviews ; Lymphoma ; Lymphoma, Non-Hodgkin - genetics ; Male ; Mantle cell lymphoma ; Middle Aged ; Non Hodgkin lymphoma ; Odds Ratio ; Oncology ; Original Paper ; Polymorphism, Single Nucleotide ; Public Health ; Translocation, Genetic ; Transplants & implants ; Tumor Necrosis Factor-alpha - genetics ; Tumor necrosis factor-TNF ; Young Adult</subject><ispartof>Cancer causes & control, 2010-05, Vol.21 (5), p.759-769</ispartof><rights>2010 Springer</rights><rights>Springer Science+Business Media B.V. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-b4b6f6d9cf5fbe21ab265374321a14889217793c8fe0405e11c9c01c70ce86613</citedby><cites>FETCH-LOGICAL-c486t-b4b6f6d9cf5fbe21ab265374321a14889217793c8fe0405e11c9c01c70ce86613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40645875$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40645875$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,58216,58449</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20087644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120296123$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernberg, Pia</creatorcontrib><creatorcontrib>Chang, Ellen T</creatorcontrib><creatorcontrib>Duvefelt, Kristina</creatorcontrib><creatorcontrib>Hjalgrim, Henrik</creatorcontrib><creatorcontrib>Eloranta, Sandra</creatorcontrib><creatorcontrib>Sørensen, Karina Meden</creatorcontrib><creatorcontrib>Porwit, Anna</creatorcontrib><creatorcontrib>Humphreys, Keith</creatorcontrib><creatorcontrib>Melbye, Mads</creatorcontrib><creatorcontrib>Ekström Smedby, Karin</creatorcontrib><title>Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><addtitle>Cancer Causes Control</addtitle><description>Background Tumor necrosis factor (TNF) and interleukin 10 (IL10) are promising candidate susceptibility genes for non-Hodgkin lymphoma (NHL). Chromosomal translocation breakpoint genes are of interest, given their documented involvement in lymphoma progression. Methods We analyzed 11 polymorphisms in BCL2, CCND1, MYC, TNF, and IL10 in a large, population-based, Danish-Swedish case-control study including 2,449 NHL cases and 1,980 controls. Relative risk of NHL was computed as odds ratios (OR). Results There was no clear evidence of associations between variants in BCL2, CCND1, and MYC and risk of NHL overall or subtypes. TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for minor allele homozygosity), T-cell lymphoma (OR 2.54, CI 1.27-5.09) and mantle cell lymphoma (OR 2.84, CI 1.38-5.87). IL10 rs1800890 was associated with risk of diffuse large B-cell lymphoma (OR 1.41, CI 1.08-1.85 for minor allele homozygosity) and mantle cell lymphoma (OR 1.77, CI 1.04-3.00). We did not replicate a previously reported interaction with autoimmunity. Conclusions We found no support for a role of the studied variants in BCL2, CCND1, or MYC in risk of NHL or subtypes, but we provide further evidence of putative susceptibility loci in TNF and IL10 for specific NHL subtypes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Autoimmune diseases</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Cell cycle</subject><subject>Cyclin D1 - genetics</subject><subject>Cytokines</subject><subject>DNA</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genes</subject><subject>Genes, bcl-2 - genetics</subject><subject>Genes, myc - genetics</subject><subject>Genetic variation</subject><subject>Genomics</subject><subject>Genotypes</subject><subject>Hardy Weinberg law</subject><subject>Hematology</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Interleukin-10 - genetics</subject><subject>Interviews</subject><subject>Lymphoma</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Male</subject><subject>Mantle cell lymphoma</subject><subject>Middle Aged</subject><subject>Non Hodgkin lymphoma</subject><subject>Odds Ratio</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Public Health</subject><subject>Translocation, Genetic</subject><subject>Transplants & implants</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor necrosis factor-TNF</subject><subject>Young Adult</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhS0EokPhAVgAUTesAvf6N1lWFW2RKrGAri3H40wzk9jBTkDz9niaYZBYwMpXPt859tUh5DXCBwRQHxOCELQEhLIWwMv9E7JCoVipKBVPyQpqoUpBOTsjL1LaAoCQFJ6TMwpQKcn5ikw3zrups8UPEzszdcEXnS_sQwxDSGEwfTFF41Mf7CI20ZndGDo_Fcavi24YZu-Kdvb2Ud7ktPSoxC7titAWPvjyNqw3uxzb74fxIYe-JM9a0yf36niek_vrT9-ubsu7Lzefry7vSssrOZUNb2Qr17VtRds4iqahUjDFWR6RV1VNUama2ap1wEE4RFtbQKvAukpKZOekXHLTTzfOjR5jN5i418F0-ni1y5PTQjDJD_z7hR9j-D67NOmhS9b1vfEuzEkrzhVQ4Or_JGOiRoUykxd_kdswR5_X1hQZIhPIMoQLZGNIKbr29FUEfahaL1XrXLU-VK332fP2GDw3g1ufHL-7zQA9bp8lv3Hxz8v_Sn2zmLZpCvEUykFyUSmR9XeL3pqgzSa3rO-_UkAGWDFKK85-AREJyBo</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Fernberg, Pia</creator><creator>Chang, Ellen T</creator><creator>Duvefelt, Kristina</creator><creator>Hjalgrim, Henrik</creator><creator>Eloranta, Sandra</creator><creator>Sørensen, Karina Meden</creator><creator>Porwit, Anna</creator><creator>Humphreys, Keith</creator><creator>Melbye, Mads</creator><creator>Ekström Smedby, Karin</creator><general>Dordrecht : Springer Netherlands</general><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>7U1</scope><scope>7U2</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20100501</creationdate><title>Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma</title><author>Fernberg, Pia ; Chang, Ellen T ; Duvefelt, Kristina ; Hjalgrim, Henrik ; Eloranta, Sandra ; Sørensen, Karina Meden ; Porwit, Anna ; Humphreys, Keith ; Melbye, Mads ; Ekström Smedby, Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-b4b6f6d9cf5fbe21ab265374321a14889217793c8fe0405e11c9c01c70ce86613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Autoimmune diseases</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Cell cycle</topic><topic>Cyclin D1 - 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Academic</collection><collection>Immunology Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernberg, Pia</au><au>Chang, Ellen T</au><au>Duvefelt, Kristina</au><au>Hjalgrim, Henrik</au><au>Eloranta, Sandra</au><au>Sørensen, Karina Meden</au><au>Porwit, Anna</au><au>Humphreys, Keith</au><au>Melbye, Mads</au><au>Ekström Smedby, Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma</atitle><jtitle>Cancer causes & control</jtitle><stitle>Cancer Causes Control</stitle><addtitle>Cancer Causes Control</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>21</volume><issue>5</issue><spage>759</spage><epage>769</epage><pages>759-769</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Background Tumor necrosis factor (TNF) and interleukin 10 (IL10) are promising candidate susceptibility genes for non-Hodgkin lymphoma (NHL). Chromosomal translocation breakpoint genes are of interest, given their documented involvement in lymphoma progression. Methods We analyzed 11 polymorphisms in BCL2, CCND1, MYC, TNF, and IL10 in a large, population-based, Danish-Swedish case-control study including 2,449 NHL cases and 1,980 controls. Relative risk of NHL was computed as odds ratios (OR). Results There was no clear evidence of associations between variants in BCL2, CCND1, and MYC and risk of NHL overall or subtypes. TNF rs1800629 was associated with risk of NHL (OR 1.53, 95% confidence interval, CI, 1.06-2.19 for minor allele homozygosity), T-cell lymphoma (OR 2.54, CI 1.27-5.09) and mantle cell lymphoma (OR 2.84, CI 1.38-5.87). IL10 rs1800890 was associated with risk of diffuse large B-cell lymphoma (OR 1.41, CI 1.08-1.85 for minor allele homozygosity) and mantle cell lymphoma (OR 1.77, CI 1.04-3.00). We did not replicate a previously reported interaction with autoimmunity. Conclusions We found no support for a role of the studied variants in BCL2, CCND1, or MYC in risk of NHL or subtypes, but we provide further evidence of putative susceptibility loci in TNF and IL10 for specific NHL subtypes.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>20087644</pmid><doi>10.1007/s10552-010-9504-y</doi><tpages>11</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Autoimmune diseases Biomedical and Life Sciences Biomedicine Blood Cancer Cancer Research Case-Control Studies Cell cycle Cyclin D1 - genetics Cytokines DNA Epidemiology Female Genes Genes, bcl-2 - genetics Genes, myc - genetics Genetic variation Genomics Genotypes Hardy Weinberg law Hematology HIV Human immunodeficiency virus Humans Infections Interleukin-10 - genetics Interviews Lymphoma Lymphoma, Non-Hodgkin - genetics Male Mantle cell lymphoma Middle Aged Non Hodgkin lymphoma Odds Ratio Oncology Original Paper Polymorphism, Single Nucleotide Public Health Translocation, Genetic Transplants & implants Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF Young Adult |
| title | Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma |
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