Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning

Intraindividual variability (IIV) reflects lawful but transient within-person changes in performance. Increased IIV in cognition shares systematic associations with numerous conditions characterized by alterations in dopamine (DA) neuromodulation (e.g., old age, ADHD, schizophrenia, and Parkinson�...

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Bibliographic Details
Published in:Neuropsychologia 2009-09, Vol.47 (11), p.2299-2304
Main Authors: MacDonald, Stuart W.S., Cervenka, Simon, Farde, Lars, Nyberg, Lars, Bäckman, Lars
Format: Article
Language:English
Subjects:
Adult
Aged
Behavioral psychophysiology
Biological and medical sciences
Carbon Isotopes - metabolism
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Dopamine
Executive functioning
Female
Fundamental and applied biological sciences. Psychology
Human
Humans
Individuality
Intraindividual variability
Learning. Memory
Male
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Memory
Middle Aged
Neuropsychological Tests
Neurotransmission and behavior
PET
Positron-Emission Tomography - methods
Problem Solving - physiology
Protein Binding
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Raclopride - metabolism
Radioligand Assay
Reaction Time
Receptors, Dopamine D2 - metabolism
Recognition (Psychology) - physiology
Recognition memory
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Summary:Intraindividual variability (IIV) reflects lawful but transient within-person changes in performance. Increased IIV in cognition shares systematic associations with numerous conditions characterized by alterations in dopamine (DA) neuromodulation (e.g., old age, ADHD, schizophrenia, and Parkinson's disease). In a group of normal middle-aged adults, we examined links between PET-derived measures of D2 receptor binding in striatum, orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and hippocampus (HC) and IIV for tasks assessing recognition memory and executive functioning. An index of IIV, the intraindividual standard deviation (ISD), was computed across successful response latency trials for each cognitive outcome. Lower D2 binding in OC, ACC, and HC, but not striatum, was associated with increasing ISDs for the memory and executive measures. Consistent with neurocomputational models, the present findings suggest a role for extrastriatal DA neurotransmission in modulating variability in cognitive functioning.
ISSN:0028-3932
1873-3514
1873-3514
DOI:10.1016/j.neuropsychologia.2009.01.016