Neuronal changes in psoriasis exacerbation

Background The nervous system contributes to inflammatory skin diseases. Objective The aim of this investigation was to study the neuronal contribution to psoriasis at the remission and exacerbation phases. Methods We examined the expression of the neuronal markers protein gene product 9.5 (PGP 9.5)...

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Bibliographic Details
Published in:Journal of the European Academy of Dermatology and Venereology 2009-11, Vol.23 (11), p.1240-1245
Main Authors: El-Nour, H, Santos, A, Nordin, M, Jonsson, P, Svensson, M, Nordlind, K, Berg, M
Format: Article
Language:English
Subjects:
Adult
Biomarkers - metabolism
Female
GAP-43
Humans
Immunohistochemistry
innervation
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Microscopy, Fluorescence
Middle Aged
neurokinin-1 receptor
Neurons - metabolism
Neurons - pathology
PGP 9
PGP 9.5
psoriasis
Psoriasis - metabolism
Psoriasis - pathology
substance P
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Summary:Background The nervous system contributes to inflammatory skin diseases. Objective The aim of this investigation was to study the neuronal contribution to psoriasis at the remission and exacerbation phases. Methods We examined the expression of the neuronal markers protein gene product 9.5 (PGP 9.5), growth‐associated protein‐43 (GAP‐43) and substance P, in addition to its receptor (R), neurokinin‐1R (NK‐1R) in psoriatic skin from seven female patients at remission and exacerbation, using immunohistochemistry. Results The number of epidermal PGP 9.5 immunoreactive nerve fibres in the involved skin during exacerbation was decreased (P 
ISSN:0926-9959
1468-3083
1468-3083
DOI:10.1111/j.1468-3083.2009.03287.x