Is the Association Between Low Birth Weight and Asthma Independent of Genetic and Shared Environmental Factors?

Epidemiologic evidence linking birth weight and asthma is inconsistent. The authors examined the association between birth weight and asthma during childhood and adult life in twins. Using prospectively collected data on 21,588 like-sexed Swedish twins of known zygosity born in 1928–1952, they first...

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Bibliographic Details
Published in:American journal of epidemiology 2009-06, Vol.169 (11), p.1337-1343
Main Authors: Villamor, Eduardo, Iliadou, Anastasia, Cnattingius, Sven
Format: Article
Language:English
Subjects:
Adolescent
Analysis. Health state
Asthma
Asthma - epidemiology
Asthma - genetics
Biological and medical sciences
Birth weight
Case-Control Studies
Child
Child, Preschool
Chronic obstructive pulmonary disease, asthma
confounding factors (epidemiology)
Diseases in Twins - epidemiology
Diseases in Twins - genetics
Diseases of mother, fetus and pregnancy
Environment
Epidemiology
General aspects
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Incidence
Infant
Infant, Low Birth Weight
Infant, Newborn
Interviews as Topic
Medical sciences
Medicin och hälsovetenskap
Miscellaneous
Pneumology
Pregnancy. Fetus. Placenta
Prevalence
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Registries
Regression Analysis
Risk Factors
Surveys and Questionnaires
Sweden - epidemiology
Twins
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Summary:Epidemiologic evidence linking birth weight and asthma is inconsistent. The authors examined the association between birth weight and asthma during childhood and adult life in twins. Using prospectively collected data on 21,588 like-sexed Swedish twins of known zygosity born in 1928–1952, they first conducted a cohort study to examine the risk of asthma in relation to birth weight. Next, they conducted nested co-twin control analyses among 643 dizygotic and 365 monozygotic twin pairs discordant for asthma to ascertain whether the association between birth weight and asthma could be confounded by genetic and shared environmental exposures. In the cohort analysis, birth weight of
ISSN:0002-9262
1476-6256
1476-6256
DOI:10.1093/aje/kwp054