Where Are We With the Management of Hypertension? From Science to Clinical Practice

The management of elevated blood pressure in patients at high cardiovascular risk is still a subject of debate. The authors review current international guidelines and results of large clinical trials and recent meta‐analyses to discuss the different approaches in patients at high risk for cardiovas...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2009-02, Vol.11 (2), p.66-73
Main Authors: Farsang, Csaba, Naditch‐Brule, Lisa, Avogaro, Angelo, Östergren, Jan, Verdecchia, Paolo, Maggioni, Aldo, Van De Borne, Philippe, Lins, Robert, Roca‐Cusachs, Alexandre
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Calcium Channel Blockers - therapeutic use
Comorbidity
Diabetes Mellitus - diagnosis
Diabetes Mellitus - epidemiology
Diet, Fat-Restricted
Diet, Sodium-Restricted
Disease Progression
Diuretics - therapeutic use
Drug Therapy, Combination
Female
Humans
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - therapy
Medicin och hälsovetenskap
Metabolic Syndrome - diagnosis
Metabolic Syndrome - epidemiology
Middle Aged
Practice Guidelines as Topic
Randomized Controlled Trials as Topic
Review Paper
Severity of Illness Index
Treatment Outcome
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Summary:The management of elevated blood pressure in patients at high cardiovascular risk is still a subject of debate. The authors review current international guidelines and results of large clinical trials and recent meta‐analyses to discuss the different approaches in patients at high risk for cardiovascular events. The different treatment options are considered in view of the modern approach and of the different classes of drugs (diuretics, angiotensin‐converting enzyme inhibitors, calcium channel blockers, β‐blockers, and angiotensin II receptor blockers) currently in use. A case report is presented as an illustration of the difficulties related to the management of high blood pressure in patients at increased risk. The benefits of the use of 2 medications that include an inhibitor of the renin‐angiotensin‐aldosterone system and a calcium channel blocker or a diuretic are discussed. Choosing the proper drugs and correct doses are important considerations for the long‐term management of hypertension.
ISSN:1524-6175
1751-7176
1751-7176
DOI:10.1111/j.1751-7176.2008.00066.x