Overweight, obesity and risk of haematological malignancies: A cohort study of Swedish and Finnish twins

Abstract Background Obesity is related to an increased risk of several forms of cancer. However, findings from studies on haematological malignancies are inconsistent. Methods We used prospectively collected data from two Swedish twin cohorts and the Finnish Twin Cohort (in total 70,067 persons) to...

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Bibliographic Details
Published in:European Journal of Cancer 2009-05, Vol.45 (7), p.1232-1238
Main Authors: Söderberg, Karin C, Kaprio, Jaakko, Verkasalo, Pia K, Pukkala, Eero, Koskenvuo, Markku, Lundqvist, Ellen, Feychting, Maria
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Body mass index
Female
Finland
Hematologic Neoplasms - etiology
Hematology, Oncology and Palliative Medicine
Humans
Leukaemia
Leukemia - etiology
Lymphoma
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Multiple Myeloma - etiology
Myeloma
Obesity
Obesity - complications
Overweight - complications
Pharmacology. Drug treatments
Proportional Hazards Models
Prospective Studies
Risk
Risk factors
Sex Factors
Sweden
Tumors
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Summary:Abstract Background Obesity is related to an increased risk of several forms of cancer. However, findings from studies on haematological malignancies are inconsistent. Methods We used prospectively collected data from two Swedish twin cohorts and the Finnish Twin Cohort (in total 70,067 persons) to study the effects of overweight and obesity on the development of leukaemia, non-Hodgkin lymphoma, Hodgkin’s lymphoma and myeloma. The cohorts were followed from baseline through 2002 (Sweden) and through 2004 (Finland). Results We found a risk increase of myeloma with a relative risk (RR) of 2.1 (95% confidence interval [CI] 1.1–3.7) among obese persons, a RR of 2.5 (1.0–6.2) for chronic myeloid leukaemia and a RR of 2.7 (0.8–9.6) for acute lymphoblastic leukaemia among overweight persons as compared to normal-weighted ones. Conclusions Our results add further evidence suggesting that overweight and obesity may have an impact on some haematological malignancies, in particular myeloma.
ISSN:0959-8049
1879-0852
1879-0852
1359-6349
DOI:10.1016/j.ejca.2008.11.004