Cardiac doses from Swedish breast cancer radiotherapy since the 1950s

Abstract Purpose To estimate cardiac doses from breast cancer radiotherapy in Sweden from the 1950s to the 1990s. These doses will contribute to deriving dose–response relationships for the risk of radiation-induced heart disease. Materials and methods The Swedish nationwide cancer register was used...

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Bibliographic Details
Published in:Radiotherapy and oncology 2009-01, Vol.90 (1), p.127-135
Main Authors: Taylor, Carolyn W, Nisbet, Andrew, McGale, Paul, Goldman, Ulla, Darby, Sarah C, Hall, Per, Gagliardi, Giovanna
Format: Article
Language:English
Subjects:
Breast cancer radiotherapy
Breast Neoplasms - radiotherapy
Dose-Response Relationship, Radiation
Female
Heart - radiation effects
Hematology, Oncology and Palliative Medicine
Humans
Long-term effects
Lymph Nodes - radiation effects
Medicin och hälsovetenskap
Radiation Dosage
Radiation-induced heart disease
Registries
Scattering, Radiation
Sweden - epidemiology
Time Factors
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Summary:Abstract Purpose To estimate cardiac doses from breast cancer radiotherapy in Sweden from the 1950s to the 1990s. These doses will contribute to deriving dose–response relationships for the risk of radiation-induced heart disease. Materials and methods The Swedish nationwide cancer register was used to identify women irradiated for breast cancer in the Stockholm area. Virtual simulation, computed tomography planning, and manual planning were used to reconstruct radiotherapy regimens. Estimates of heart and coronary artery dose were derived for each woman. Results Cardiac doses were assessed in 358 women. Mean heart dose varied from
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2008.09.029