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Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome
Background: Focal lymphocytic infiltrates of minor salivary glands are considered target‐organ related signs of Sjögren’s syndrome. The percentages of plasma cells expressing IgA, IgG and IgM in minor salivary gland biopsies have also been suggested as useful in establishing a diagnosis of Sjögren’...
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| Published in: | Journal of oral pathology & medicine 2009-03, Vol.38 (3), p.282-288 |
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| creator | Salomonsson, Stina Rozell, Barbro Lundh Heimburger, Mikael Wahren-Herlenius, Marie |
| description | Background: Focal lymphocytic infiltrates of minor salivary glands are considered target‐organ related signs of Sjögren’s syndrome. The percentages of plasma cells expressing IgA, IgG and IgM in minor salivary gland biopsies have also been suggested as useful in establishing a diagnosis of Sjögren’s syndrome, and this study aimed at evaluating this method.
Methods: All biopsies from patients under investigation for Sjögren’s syndrome (n = 210) at our department during 4 years were analyzed for IgA, IgG and IgM producing cells by immunohistochemistry, and related to Sjögren classification parameters.
Results: A focus score ≥1 was observed in 67/210 patients and the frequency of IgA producing cells was |
| doi_str_mv | 10.1111/j.1600-0714.2008.00697.x |
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| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_562250</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67000135</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5227-59df6b5b11e504d04a5f673c3dfbe048346d2f1ecc0aecc63024d88eeecd67da3</originalsourceid><addsrcrecordid>eNqNktGO1CAUhonRuOPqKxhu1KvWAxTaJt7oRlc3s666Y7wktNBZZtsywtSdeTFfwBeTOnXmykQu4AS-n3M4PwhhAimJ4-UqJQIggZxkKQUoUgBR5un2HpodDu6jGZSQJZQTeoIehbACIDnLyEN0Qoq8ZJTDDC0ube88Dqq1P5Tf4WWreo1t1w29u7Fh41q33GHb482NwdqqZe-CDdg1eO1tNyquV79-Lr3pXwQcdr32rjOP0YNGtcE8mdZT9PXd28XZ-2R-df7h7PU8qTmlecJL3YiKV4QYDpmGTPFG5KxmuqkMZAXLhKYNMXUNKk6CAc10URhjai1yrdgpSvb3hjuzHio5lSSdsnLauo2RkVzQ-NrIl__k197po-ivkJCCiVJkNGqf77UR_D6YsJGdDbVpY7-MG4IUOcT-Mh7BYg_W3oXgTXNIQ0CO7smVHE2So0lydE_-cU9uo_TplGOoOqOPwsmuCDybABVq1TZe9bUNB47GcotCkMi92nN3tjW7_y5AXlx9isGxr_EDmO1BrvxtfCbLufz28VzOF9dvxJfPl_KC_QYG-8gx</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67000135</pqid></control><display><type>article</type><title>Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome</title><source>Wiley</source><creator>Salomonsson, Stina ; Rozell, Barbro Lundh ; Heimburger, Mikael ; Wahren-Herlenius, Marie</creator><creatorcontrib>Salomonsson, Stina ; Rozell, Barbro Lundh ; Heimburger, Mikael ; Wahren-Herlenius, Marie</creatorcontrib><description>Background: Focal lymphocytic infiltrates of minor salivary glands are considered target‐organ related signs of Sjögren’s syndrome. The percentages of plasma cells expressing IgA, IgG and IgM in minor salivary gland biopsies have also been suggested as useful in establishing a diagnosis of Sjögren’s syndrome, and this study aimed at evaluating this method.
Methods: All biopsies from patients under investigation for Sjögren’s syndrome (n = 210) at our department during 4 years were analyzed for IgA, IgG and IgM producing cells by immunohistochemistry, and related to Sjögren classification parameters.
Results: A focus score ≥1 was observed in 67/210 patients and the frequency of IgA producing cells was <70% in 42/210 patients. Sufficient clinical data for classification of disease were available for 57/210 patients. Patients were classified as having primary Sjögren’s syndrome (pSS) (n = 9), secondary Sjögren’s syndrome (sSS) (n = 12) or non‐Sjögren’s syndrome (non‐SS) (n = 36). IgA expressing cells were significantly decreased (P < 0.01) and IgG expressing cells significantly increased (P < 0.02) in patients with pSS compared to non‐SS. Also, increased numbers of salivary gland IgG producing plasma cells correlated with increased IgG serum levels (P < 0.001). However, there was no significant difference between sSS and non‐SS with regard to IgA, IgG or IgM expressing cells in the glands.
Conclusions: Our results support previous reports indicating the relevance of quantitative evaluation of Ig isotype expression in plasma cells in the clinical investigation of Sjögren’s syndrome and further indicate a difference in plasma cell populations between pSS and sSS.</description><identifier>ISSN: 0904-2512</identifier><identifier>ISSN: 1600-0714</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2008.00697.x</identifier><identifier>PMID: 18793250</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Biopsy ; Cell Count ; chronic inflammation ; Dentistry ; Female ; Humans ; Immunoglobulin A - biosynthesis ; Immunoglobulin G - biosynthesis ; Immunoglobulin M - biosynthesis ; Immunohistochemistry ; Immunophenotyping ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Mouth Mucosa - immunology ; Mouth Mucosa - pathology ; Otorhinolaryngology. Stomatology ; plasma cells ; Plasma Cells - metabolism ; salivary gland ; Salivary Glands, Minor - immunology ; Salivary Glands, Minor - pathology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sjogren's Syndrome - classification ; Sjogren's Syndrome - immunology ; Sjogren's Syndrome - pathology ; Sjögren's syndrome</subject><ispartof>Journal of oral pathology & medicine, 2009-03, Vol.38 (3), p.282-288</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5227-59df6b5b11e504d04a5f673c3dfbe048346d2f1ecc0aecc63024d88eeecd67da3</citedby><cites>FETCH-LOGICAL-c5227-59df6b5b11e504d04a5f673c3dfbe048346d2f1ecc0aecc63024d88eeecd67da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21188861$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18793250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118369642$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Salomonsson, Stina</creatorcontrib><creatorcontrib>Rozell, Barbro Lundh</creatorcontrib><creatorcontrib>Heimburger, Mikael</creatorcontrib><creatorcontrib>Wahren-Herlenius, Marie</creatorcontrib><title>Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background: Focal lymphocytic infiltrates of minor salivary glands are considered target‐organ related signs of Sjögren’s syndrome. The percentages of plasma cells expressing IgA, IgG and IgM in minor salivary gland biopsies have also been suggested as useful in establishing a diagnosis of Sjögren’s syndrome, and this study aimed at evaluating this method.
Methods: All biopsies from patients under investigation for Sjögren’s syndrome (n = 210) at our department during 4 years were analyzed for IgA, IgG and IgM producing cells by immunohistochemistry, and related to Sjögren classification parameters.
Results: A focus score ≥1 was observed in 67/210 patients and the frequency of IgA producing cells was <70% in 42/210 patients. Sufficient clinical data for classification of disease were available for 57/210 patients. Patients were classified as having primary Sjögren’s syndrome (pSS) (n = 9), secondary Sjögren’s syndrome (sSS) (n = 12) or non‐Sjögren’s syndrome (non‐SS) (n = 36). IgA expressing cells were significantly decreased (P < 0.01) and IgG expressing cells significantly increased (P < 0.02) in patients with pSS compared to non‐SS. Also, increased numbers of salivary gland IgG producing plasma cells correlated with increased IgG serum levels (P < 0.001). However, there was no significant difference between sSS and non‐SS with regard to IgA, IgG or IgM expressing cells in the glands.
Conclusions: Our results support previous reports indicating the relevance of quantitative evaluation of Ig isotype expression in plasma cells in the clinical investigation of Sjögren’s syndrome and further indicate a difference in plasma cell populations between pSS and sSS.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cell Count</subject><subject>chronic inflammation</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunohistochemistry</subject><subject>Immunophenotyping</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - immunology</subject><subject>Mouth Mucosa - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>plasma cells</subject><subject>Plasma Cells - metabolism</subject><subject>salivary gland</subject><subject>Salivary Glands, Minor - immunology</subject><subject>Salivary Glands, Minor - pathology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Sjogren's Syndrome - classification</subject><subject>Sjogren's Syndrome - immunology</subject><subject>Sjogren's Syndrome - pathology</subject><subject>Sjögren's syndrome</subject><issn>0904-2512</issn><issn>1600-0714</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNktGO1CAUhonRuOPqKxhu1KvWAxTaJt7oRlc3s666Y7wktNBZZtsywtSdeTFfwBeTOnXmykQu4AS-n3M4PwhhAimJ4-UqJQIggZxkKQUoUgBR5un2HpodDu6jGZSQJZQTeoIehbACIDnLyEN0Qoq8ZJTDDC0ube88Dqq1P5Tf4WWreo1t1w29u7Fh41q33GHb482NwdqqZe-CDdg1eO1tNyquV79-Lr3pXwQcdr32rjOP0YNGtcE8mdZT9PXd28XZ-2R-df7h7PU8qTmlecJL3YiKV4QYDpmGTPFG5KxmuqkMZAXLhKYNMXUNKk6CAc10URhjai1yrdgpSvb3hjuzHio5lSSdsnLauo2RkVzQ-NrIl__k197po-ivkJCCiVJkNGqf77UR_D6YsJGdDbVpY7-MG4IUOcT-Mh7BYg_W3oXgTXNIQ0CO7smVHE2So0lydE_-cU9uo_TplGOoOqOPwsmuCDybABVq1TZe9bUNB47GcotCkMi92nN3tjW7_y5AXlx9isGxr_EDmO1BrvxtfCbLufz28VzOF9dvxJfPl_KC_QYG-8gx</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Salomonsson, Stina</creator><creator>Rozell, Barbro Lundh</creator><creator>Heimburger, Mikael</creator><creator>Wahren-Herlenius, Marie</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>200903</creationdate><title>Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome</title><author>Salomonsson, Stina ; Rozell, Barbro Lundh ; Heimburger, Mikael ; Wahren-Herlenius, Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5227-59df6b5b11e504d04a5f673c3dfbe048346d2f1ecc0aecc63024d88eeecd67da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cell Count</topic><topic>chronic inflammation</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunohistochemistry</topic><topic>Immunophenotyping</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Mouth Mucosa - immunology</topic><topic>Mouth Mucosa - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>plasma cells</topic><topic>Plasma Cells - metabolism</topic><topic>salivary gland</topic><topic>Salivary Glands, Minor - immunology</topic><topic>Salivary Glands, Minor - pathology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Sjogren's Syndrome - classification</topic><topic>Sjogren's Syndrome - immunology</topic><topic>Sjogren's Syndrome - pathology</topic><topic>Sjögren's syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salomonsson, Stina</creatorcontrib><creatorcontrib>Rozell, Barbro Lundh</creatorcontrib><creatorcontrib>Heimburger, Mikael</creatorcontrib><creatorcontrib>Wahren-Herlenius, Marie</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salomonsson, Stina</au><au>Rozell, Barbro Lundh</au><au>Heimburger, Mikael</au><au>Wahren-Herlenius, Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2009-03</date><risdate>2009</risdate><volume>38</volume><issue>3</issue><spage>282</spage><epage>288</epage><pages>282-288</pages><issn>0904-2512</issn><issn>1600-0714</issn><eissn>1600-0714</eissn><abstract>Background: Focal lymphocytic infiltrates of minor salivary glands are considered target‐organ related signs of Sjögren’s syndrome. The percentages of plasma cells expressing IgA, IgG and IgM in minor salivary gland biopsies have also been suggested as useful in establishing a diagnosis of Sjögren’s syndrome, and this study aimed at evaluating this method.
Methods: All biopsies from patients under investigation for Sjögren’s syndrome (n = 210) at our department during 4 years were analyzed for IgA, IgG and IgM producing cells by immunohistochemistry, and related to Sjögren classification parameters.
Results: A focus score ≥1 was observed in 67/210 patients and the frequency of IgA producing cells was <70% in 42/210 patients. Sufficient clinical data for classification of disease were available for 57/210 patients. Patients were classified as having primary Sjögren’s syndrome (pSS) (n = 9), secondary Sjögren’s syndrome (sSS) (n = 12) or non‐Sjögren’s syndrome (non‐SS) (n = 36). IgA expressing cells were significantly decreased (P < 0.01) and IgG expressing cells significantly increased (P < 0.02) in patients with pSS compared to non‐SS. Also, increased numbers of salivary gland IgG producing plasma cells correlated with increased IgG serum levels (P < 0.001). However, there was no significant difference between sSS and non‐SS with regard to IgA, IgG or IgM expressing cells in the glands.
Conclusions: Our results support previous reports indicating the relevance of quantitative evaluation of Ig isotype expression in plasma cells in the clinical investigation of Sjögren’s syndrome and further indicate a difference in plasma cell populations between pSS and sSS.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18793250</pmid><doi>10.1111/j.1600-0714.2008.00697.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Biopsy Cell Count chronic inflammation Dentistry Female Humans Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Immunohistochemistry Immunophenotyping Male Medical sciences Medicin och hälsovetenskap Middle Aged Mouth Mucosa - immunology Mouth Mucosa - pathology Otorhinolaryngology. Stomatology plasma cells Plasma Cells - metabolism salivary gland Salivary Glands, Minor - immunology Salivary Glands, Minor - pathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sjogren's Syndrome - classification Sjogren's Syndrome - immunology Sjogren's Syndrome - pathology Sjögren's syndrome |
| title | Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome |
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