clinical evaluation of the Janus Web Application, a software screening tool for drug-drug interactions

Purpose To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). Methods One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into h...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2008-12, Vol.64 (12), p.1209-1214
Main Authors: Mannheimer, Buster, Ulfvarson, Johanna, Eklöf, Sara, Bergqvist, Monica, von Bahr, Christer
Format: Article
Language:English
Subjects:
Adverse drug reaction
Aged
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Computerized physician order entry
Decision Support Systems, Clinical
Drug Interactions
Drug Utilization Review - methods
Drug Utilization Review - statistics & numerical data
Drug-Related Side Effects and Adverse Reactions
Female
Humans
Male
Medical order entry systems
Medical Records
Medical sciences
Medicin och hälsovetenskap
Patient safety
Performance evaluation
Pharmaceutical Preparations - administration & dosage
Pharmacoepidemiology and Prescription
Pharmacology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Software
Software validation
Surveys and Questionnaires
Sweden
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Summary:Purpose To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). Methods One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into his/her medical records provided complementing information. A clinical pharmacologist judged which potential DDIs were clinically relevant. Potentially relevant DDIs identified by the JWA were then correlated with clinically relevant DDIs. Results A total of 150 significant potential DDIs were found. Sixteen percent (24/150) were judged to be clinically relevant. Conclusions A very small proportion of DDIs was considered clinically relevant in the specific clinical context. To optimise the software's user-friendliness, the following points need to be considered: the possibility of eliminating trivial potential DDIs, individualising drug alerts, and providing written information, accessible via a hyperlink.
ISSN:0031-6970
1432-1041
1432-1041
DOI:10.1007/s00228-008-0547-x