In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

Abstract Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to p...

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Bibliographic Details
Published in:Leukemia research 2009-01, Vol.33 (1), p.46-53
Main Authors: Lönnerholm, Gudmar, Thörn, Ingrid, Sundström, Christer, Frost, Britt-Marie, Abrahamsson, Jonas, Behrendtz, Mikael, Heldrup, Jesper, Jacobsson, Stefan, Li, AiHong, Olofsson, Tor, Porwit, Anna, Söderhäll, Stefan, Larsson, Rolf, Forestier, Erik
Format: Article
Language:English
Subjects:
21
Acute lymphoblastic leukemia
administration & dosage
Adolescent
Antineoplastic Combined Chemotherapy Protocols
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer and Oncology
Cancer och onkologi
Chemistry
Child
Child, Preschool
Childhood
Clinical chemistry
Clinical Medicine
diagnosis
Doxorubicin
Doxorubicin - administration & dosage
drug therapy
Hematologi
Hematology
Hematology, Oncology and Palliative Medicine
Humans
In vitro drug resistance
In Vitro Techniques
Infant
Kemi
Klinisk kemi
Klinisk medicin
Medical and Health Sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
MRD
Neoplasm
Neoplasm, Residual - diagnosis
pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Prednisolone
Prednisolone - administration & dosage
Preschool
Residual
t(12
21)
therapeutic use
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Summary:Abstract Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone ( p < 0.001) and doxorubicin ( p = 0.017), drugs administered during induction therapy. In patients with t (12;21) ( n = 20), in vitro sensitivity to doxorubicin was an independent factor for MRD
ISSN:0145-2126
1873-5835
1873-5835
DOI:10.1016/j.leukres.2008.06.012