Exhaled nitric oxide monitoring in COPD using a portable analyzer

Abstract Background The exhaled nitric oxide (FeNO) is a non-invasive marker of airway inflammation in asthma. A very recent statement has suggested FeNO as potential outcome in chronic obstructive pulmonary disease (COPD). Recently, a new hand-held FeNO analyzer (NIOX MINO) has been developed. Pati...

Full description

Saved in:
Bibliographic Details
Published in:Pulmonary pharmacology & therapeutics 2008-08, Vol.21 (4), p.689-693
Main Authors: de Laurentiis, Guglielmo, Maniscalco, Mauro, Cianciulli, Flavia, Stanziola, Anna, Marsico, Serafino, Lundberg, Jon O, Weitzberg, Eddie, Sofia, Matteo
Format: Article
Language:English
Subjects:
Aged
Airway inflammation
Ambulatory Care
Breath Tests - instrumentation
Breath Tests - methods
Chronic obstructive pulmonary disease
Cohort Studies
Equipment Design
Exacerbation
Exhaled nitric oxide
Female
Hand-held analyzer
Humans
Luminescent Measurements - methods
Male
Medical Education
Medicin och hälsovetenskap
Middle Aged
Nitric Oxide - analysis
Nitric Oxide - metabolism
Pulmonary Disease, Chronic Obstructive - metabolism
Pulmonary/Respiratory
Reproducibility of Results
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background The exhaled nitric oxide (FeNO) is a non-invasive marker of airway inflammation in asthma. A very recent statement has suggested FeNO as potential outcome in chronic obstructive pulmonary disease (COPD). Recently, a new hand-held FeNO analyzer (NIOX MINO) has been developed. Patients and methods We have evaluated the NIOX MINO in COPD patients and monitored FeNO levels during 1-year assessment in the outpatient setting. Short-term variability in FeNO was compared using a NIOX MINO and a stationary chemiluminescence analyzer (NOA, Sensormedics) in healthy volunteers and COPD patients on two consecutive months. Long-term FeNO variability was assessed on a cohort of 70 COPD outpatients measuring FeNO for 1 year. The intra-individual FeNO coefficient of variation (eNOCoV) was taken as index FeNO long-term variability. Results In COPD there were no significant differences between NIOX MINO and NOA FeNO values recorded at baseline and 1 month later. Ninety five percent limits of agreement between NIOX MINO and NOA were—2.7 and 1.9 ppb with significant reliability ( r =0.96, p
ISSN:1094-5539
1522-9629
DOI:10.1016/j.pupt.2008.04.006