Loss to follow‐up in an international, multicentre observational study

Objective The aim of this work was to assess loss to follow‐up (LTFU) in EuroSIDA, an international multicentre observational cohort study. Methods LTFU was defined as no follow‐up visit, CD4 cell count measurement or viral load measurement after 1 January 2006. Poisson regression was used to descri...

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Bibliographic Details
Published in:HIV medicine 2008-05, Vol.9 (5), p.261-269
Main Authors: Mocroft, A, Kirk, O, Aldins, P, Chies, A, Blaxhult, A, Chentsova, N, Vetter, N, Dabis, F, Gatell, J, Lundgren, JD
Format: Article
Language:English
Subjects:
Adult
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count - methods
Europe - epidemiology
Female
Follow-Up Studies
HIV Infections - epidemiology
HIV-1
Human immunodeficiency virus
Humans
Incidence
loss to follow‐up
Male
Medicin och hälsovetenskap
Regression Analysis
survival
Viral Load - methods
vital status
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Summary:Objective The aim of this work was to assess loss to follow‐up (LTFU) in EuroSIDA, an international multicentre observational cohort study. Methods LTFU was defined as no follow‐up visit, CD4 cell count measurement or viral load measurement after 1 January 2006. Poisson regression was used to describe factors related to LTFU. Results The incidence of LTFU in 12 304 patients was 3.72 per 100 person‐years of follow‐up [95% confidence interval (CI) 3.58–3.86; 2712 LTFU] and varied among countries from 0.67 to 13.35. After adjustment, older patients, those with higher CD4 cell counts, and those who had started combination antiretroviral therapy all had lower incidences of LTFU, while injecting drug users had a higher incidence of LTFU. Compared with patients from Southern Europe and Argentina, patients from Eastern Europe had over a twofold increased incidence of LTFU after adjustment (incidence rate ratio 2.16; 95% CI 1.84–2.53; P1 year with no CD4 cell count or viral load measured during the year; 743 (27.1%) subsequently returned to follow‐up. Conclusions Some patients thought to be LTFU may have died, and efforts should be made to ascertain vital status wherever possible. A significant proportion of patients who have a year with no follow‐up visit, CD4 cell count measurement or viral load measurement subsequently return to follow‐up.
ISSN:1464-2662
1468-1293
DOI:10.1111/j.1468-1293.2008.00557.x