A low-dose intradermal hepatitis B vaccine programme in health-care workers and students is highly effective and cost saving: A retrospective follow-up survey in the clinical setting

Objective. To evaluate compliance, serologic response and the cost-benefit of a low-dose intradermal hepatitis B vaccination programme, followed by intramuscular boosters in non-responders. Material and methods. The study comprised a retrospective survey of 1521 health-care workers and 968 students....

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2008, Vol.43 (4), p.465-472
Main Authors: Sangfelt, Per, Uhnoo, Ingrid, Reichard, Olle, Weiland, Ola
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Compliance
cost-benefit
Cost-Benefit Analysis
Data Collection
Female
Gastroenterology. Liver. Pancreas. Abdomen
Health Personnel
Hepatitis B Antibodies - blood
hepatitis B vaccination
Hepatitis B Vaccines - administration & dosage
Hepatitis B Vaccines - economics
Human viral diseases
Humans
Immunization Programs
Immunization, Secondary
Infectious Disease Transmission, Patient-to-Professional - economics
Infectious Disease Transmission, Patient-to-Professional - prevention & control
Infectious diseases
Injections, Intradermal
Injections, Intramuscular
intradermal
intramuscular booster
low-dose
Male
Medical sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Middle Aged
Patient Compliance
response
Students, Medical
Vaccination - economics
Vaccines, Synthetic
Viral diseases
Viral hepatitis
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Summary:Objective. To evaluate compliance, serologic response and the cost-benefit of a low-dose intradermal hepatitis B vaccination programme, followed by intramuscular boosters in non-responders. Material and methods. The study comprised a retrospective survey of 1521 health-care workers and 968 students. Response was defined as hepatitis B antibody titres ≥10 IU/L. Non-response included vaccinees with undetectable antibodies and a hypo-response if antibodies were detectable. Results. Overall, 2145/2489 (86%) subjects completed the intradermal series, whereof 1840/2489 (74%) complied with the serological check-up. Response was achieved in 1517/1840 (82.5%), whereas 107/1840 (5.8%) had a hypo-response and 216/1840 (11.7%) had an undetectable response. In a logistic regression model, younger age (odds ratio 0.73 (95% CI: 0.65-0.82, p
ISSN:0036-5521
1502-7708
1502-7708
DOI:10.1080/00365520701733806