Severe Preeclampsia With and Without HELLP Differ With Regard to Placental Pathology

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-05, Vol.51 (5), p.1295-1299
• Main Authors: Vinnars, Marie-Therese, Wijnaendts, Liliane C.D, Westgren, Magnus, Bolte, Annemieke C, Papadogiannakis, Nikos, Nasiell, Josefine
• Format: Article
• Language: English
• Subjects: Adult; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Birth Weight - physiology; Blood and lymphatic vessels; Blood Pressure - physiology; Cardiology. Vascular system; Chorionic Villi - pathology; Diseases of mother, fetus and pregnancy; eclampsia; Female; gestational hypertension; Gynecology. Andrology. Obstetrics; HELLP Syndrome - pathology; HELLP Syndrome - physiopathology; Humans; Infant, Newborn; Infant, Small for Gestational Age - physiology; Medical sciences; Medicin och hälsovetenskap; Organ Size - physiology; Placenta - pathology; Pre-Eclampsia - pathology; Pre-Eclampsia - physiopathology; preeclampsia; Pregnancy; pregnancy hypertension; Pregnancy. Fetus. Placenta; proteinuria; Retrospective Studies; women
• ISSN: 0194-911X; 1524-4563; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.107.104844

The aim of the present study was to evaluate the histopathology in placentas from patients with severe preeclampsia with and without hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. An additional aim was to compare the prevalence of infants born small for gestational age in the 2 groups. The study is retrospective and includes 178 women who have been diagnosed at the Karolinska University Hospital Huddinge or at the Free University Medical Center between 2000 and 2005 with severe preeclampsia. A total of 96 women had severe preeclampsia without signs of HELLP (preeclampsia group), whereas 82 fulfilled the criteria for having HELLP syndrome (HELLP group). Infarction (P=0.014), intervillous thrombosis (P