Effects of synovial fluid from aseptic prosthesis loosening on collagen production in osteoblasts

Synovial fluid from a loose prosthesis may act as a vehicle for factors that regulate bone turnover. The effect of such synovial fluid on osteoblasts has been studied. Synovial fluid obtained from patients who underwent revision hip arthroplasty because of aseptic prosthesis loosening was studied re...

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Bibliographic Details
Published in:International orthopaedics 2009-06, Vol.33 (3), p.873-877
Main Authors: Tsai, Jon A., Andersson, Martin K., Ivarsson, Mikael, Granberg, Barbro, Stark, André
Format: Article
Language:English
Subjects:
Arthroplasty (hip)
Bone turnover
Cell Line, Tumor
Collagen
Collagen (type I)
Collagen Type I - genetics
Collagen Type I - metabolism
Gene expression
Gene Expression - drug effects
Hip
Humans
Medicin
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Original Paper
Orthopedics
Osteoblasts
Osteoblasts - drug effects
Osteoblasts - metabolism
Osteocalcin
Osteocalcin - metabolism
Osteogenesis
Peptide Fragments - metabolism
Procollagen - metabolism
Prosthesis Failure
Protein biosynthesis
Protein Biosynthesis - drug effects
RNA, Messenger - metabolism
Secretion
Synovial fluid
Synovial Fluid - metabolism
Tissue Extracts - pharmacology
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Summary:Synovial fluid from a loose prosthesis may act as a vehicle for factors that regulate bone turnover. The effect of such synovial fluid on osteoblasts has been studied. Synovial fluid obtained from patients who underwent revision hip arthroplasty because of aseptic prosthesis loosening was studied regarding the effect on protein synthesis, procollagen I mRNA expression, the secretion of procollagen I carboxyterminal propeptide (PICP) and osteocalcin in MG63 osteoblasts. Protein synthesis was increased and procollagen I mRNA expression was decreased by synovial fluid from patients with prosthesis loosening. Synovial fluid stimulated the total PICP in cell medium, but there was no change after correction for cell protein content in the cells. Synovial fluid in patients with prosthesis loosening has a general stimulatory effect on collagen formation and osteoblast proliferation because of a stimulatory effect on cell growth. Aseptic prosthesis loosening may be associated with an increase in bone formation.
ISSN:0341-2695
1432-5195
1432-5195
DOI:10.1007/s00264-008-0533-z