HPT axis, CSF monoamine metabolites, suicide intent and depression severity in male suicide attempters

Abstract A lower thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) in depressed women has been associated with violent suicide attempts, suicidal intent, higher lethality and suicide risk. The cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and homovanil...

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Bibliographic Details
Published in:Journal of affective disorders 2008-11, Vol.111 (1), p.119-124
Main Authors: Jokinen, Jussi, Samuelsson, Mats, Nordström, Anna-Lena, Nordström, Peter
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Control Groups
CSF 5-HIAA
CSF HVA
Depression
Depression severity
Depressive Disorder - blood
Depressive Disorder - cerebrospinal fluid
Depressive Disorder - diagnosis
Homovanillic Acid - cerebrospinal fluid
Hormones
Humans
Hydroxyindoleacetic Acid - cerebrospinal fluid
Male
Medical sciences
Medicin och hälsovetenskap
Men
Middle Aged
Mood disorders
Psychiatric Status Rating Scales
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Severity of Illness Index
Spinal Puncture
Stimulation, Chemical
Suicidal behaviour
Suicide
Suicide - psychology
Suicide - statistics & numerical data
Suicide intent
Suicide, Attempted - psychology
Suicide, Attempted - statistics & numerical data
Thyrotropin - blood
Thyrotropin - drug effects
Thyrotropin-Releasing Hormone - pharmacology
TRH test
Triiodothyronine - blood
Violence - psychology
Violence - statistics & numerical data
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Summary:Abstract A lower thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) in depressed women has been associated with violent suicide attempts, suicidal intent, higher lethality and suicide risk. The cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) levels are related to suicidal behaviour. We studied the HPT axis function in twelve male suicide attempters and eight healthy volunteers submitted to lumbar puncture and to TRH test. Suicidal behaviour and depression severity were assessed. There was no association between deltamaxTSH and violent suicidality or subsequent suicide. The deltamaxTSH correlated with CSF HVA in suicide attempters. The plasma T3 showed a negative correlation with the Beck Suicide Intent Scale and the Montgomery Asberg Depression rating scale. Dopaminergic regulatory mechanisms on the thyroid hormone activity may be altered in male suicide attempters.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2008.02.001