Protein tyrosine phosphatases: regulatory mechanisms

Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerizatio...

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Bibliographic Details
Published in:The FEBS journal 2008-03, Vol.275 (5), p.831-847
Main Authors: Hertog, Jeroen den, Östman, Arne, Böhmer, Frank-D
Format: Article
Language:English
Subjects:
(R)PTP
(receptor) protein‐tyrosine phosphate
Alternative Splicing
Animals
Binding sites
Biochemistry
Catalysis
catalytic activity
Cellular biology
differential expression
Dimerization
Humans
ligand binding
Ligands
Molecular biology
oxidation
Oxidation-Reduction
Phosphorylation
Protein Processing, Post-Translational
Protein Tyrosine Phosphatases - analysis
Protein Tyrosine Phosphatases - genetics
Protein Tyrosine Phosphatases - metabolism
Proteins
regulation
subcellular localization
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Summary:Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.
ISSN:1742-464X
1742-4658
DOI:10.1111/j.1742-4658.2008.06247.x