Familiality and heritability of binge eating disorder: Results of a case-control family study and a twin study

OBJECTIVE:: To estimate the familiality and heritability of binge eating disorder (BED). METHOD:: We used a new ACE structural equation model to estimate heritability from a case-control family study of BED conducted in the Boston area. The sample consisted of 150 overweight/obese probands with life...

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Bibliographic Details
Published in:The International journal of eating disorders 2008-03, Vol.41 (2), p.174-179
Main Authors: Javaras, Kristin N, Laird, Nan M, Reichborn-Kjennerud, Ted, Bulik, Cynthia M, Pope, Harrison G. Jr, Hudson, James I
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Binge eating
binge eating disorder
binging
Biological and medical sciences
Bulimia
Bulimia - genetics
case studies
case-control family study
Case-Control Studies
Eating behavior disorders
Eating disorders
Education, Continuing
familial aggregation
familial incidence
families
Families & family life
Female
Genetic Predisposition to Disease
Heredity
heritability
Humans
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Miscellaneous
Obesity
overweight
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Studies
Twin Studies as Topic
twin study
Twins
weight control
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Summary:OBJECTIVE:: To estimate the familiality and heritability of binge eating disorder (BED). METHOD:: We used a new ACE structural equation model to estimate heritability from a case-control family study of BED conducted in the Boston area. The sample consisted of 150 overweight/obese probands with lifetime BED by DSM-IV criteria, 150 overweight/obese probands without lifetime BED, and 888 of their first-degree relatives. We compared our findings with those from a study of binge eating (in the absence of compensatory behaviors) among 7,831 Norwegian twins. RESULTS:: The prevalence of BED differed by sex and by age. In the case-control family study, BED was found to aggregate in families, and heritability was estimated as 57% (CI: 30-77%). Including shared environment did not substantially improve the model's fit, nor did allowing sex-specific heritability. Findings from the twin study were similar. CONCLUSION:: BED appears to aggregate in families and have a significant genetic component. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord, 2008
ISSN:0276-3478
1098-108X
1098-108X
DOI:10.1002/eat.20484