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Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET

Women and men differ in serotonin associated psychiatric conditions, such as depression, anxiety and suicide. Despite this, very few studies focus on sex differences in the serotonin system. Of the biomarkers in the serotonin system, serotonin1A (5-HT1A) receptor is implicated in depression, and anx...

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Published in:NeuroImage (Orlando, Fla.) Fla.), 2008-02, Vol.39 (3), p.1408-1419
Main Authors: Jovanovic, Hristina, Lundberg, Johan, Karlsson, Per, Cerin, Åsta, Saijo, Tomoyuki, Varrone, Andrea, Halldin, Christer, Nordström, Anna-Lena
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description Women and men differ in serotonin associated psychiatric conditions, such as depression, anxiety and suicide. Despite this, very few studies focus on sex differences in the serotonin system. Of the biomarkers in the serotonin system, serotonin1A (5-HT1A) receptor is implicated in depression, and anxiety and serotonin transporter (5-HTT) is a target for selective serotonin reuptake inhibitors, psychotropic drugs used in the treatment of these disorders. The objective of the present study was to study sex related differences in the 5-HT1A receptor and 5-HTT binding potentials (BPNDs) in healthy humans, in vivo. Positron emission tomography and selective radioligands [11C]WAY100635 and [11C]MADAM were used to evaluate binding potentials for 5-HT1A receptors (14 women and 14 men) and 5-HTT (8 women and 10 men). The binding potentials were estimated both on the level of anatomical regions and voxel wise, derived by the simplified reference tissue model and wavelet/Logan plot parametric image techniques respectively. Compared to men, women had significantly higher 5-HT1A receptor and lower 5-HTT binding potentials in a wide array of cortical and subcortical brain regions. In women, there was a positive correlation between 5-HT1A receptor and 5-HTT binding potentials for the region of hippocampus. Sex differences in 5-HT1A receptor and 5-HTT BPND may reflect biological distinctions in the serotonin system contributing to sex differences in the prevalence of psychiatric disorders such as depression and anxiety. The result of the present study may help in understanding sex differences in drug treatment responses to drugs affecting the serotonin system.
doi_str_mv 10.1016/j.neuroimage.2007.10.016
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subjects Adult
Anxiety
Benzylamines - chemical synthesis
Biomarkers
Brain - diagnostic imaging
Brain Chemistry - physiology
Cerebral Cortex - diagnostic imaging
Female
Gender differences
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medical imaging
Medicin och hälsovetenskap
Men
NMR
Nuclear magnetic resonance
Piperazines - chemical synthesis
Positron-Emission Tomography
Protein Binding - physiology
Pyridines - chemical synthesis
Radiopharmaceuticals - chemical synthesis
Receptor, Serotonin, 5-HT1A - metabolism
Serotonin
Serotonin Antagonists - chemical synthesis
Serotonin Plasma Membrane Transport Proteins - metabolism
Sex Characteristics
Studies
Suicides & suicide attempts
title Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET
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