Expression of Syndecan-1 in Paired Samples of Normal and Malignant Breast Tissue from Postmenopausal Women

Background: The mammary stroma is important for modulating epithelial breast cell response to sex steroid hormones. Proteoglycans, such as syndecan-1, promote the integration of cellular signals. Materials and Methods: The immunohistochemical expression of syndecan-1 and of the androgen receptor (AR...

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Bibliographic Details
Published in:Anticancer research 2007-09, Vol.27 (5A), p.3045-3050
Main Authors: LÖFGREN, L, SAHLIN, L, JIANG, S, VON SCHOULTZ, B, FERNSTAD, R, SKOOG, L, VON SCHOULTZ, E
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers, Tumor - biosynthesis
Breast - metabolism
Breast Neoplasms - metabolism
Epithelial Cells - metabolism
Female
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Mammary gland diseases
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Postmenopause - metabolism
Receptors, Androgen - biosynthesis
Stromal Cells - metabolism
Syndecan-1 - biosynthesis
Tumors
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Summary:Background: The mammary stroma is important for modulating epithelial breast cell response to sex steroid hormones. Proteoglycans, such as syndecan-1, promote the integration of cellular signals. Materials and Methods: The immunohistochemical expression of syndecan-1 and of the androgen receptor (AR) was analyzed in paired samples of cancer and adjacent normal tissue from postmenopausal women. Results: Normal and cancer tissue showed dramatic differences in the expression of syndecan-1. In malignant breast stroma, mean values were more than 10-fold higher than in normal tissue (p
ISSN:0250-7005
1791-7530