Anorexia Nervosa and Autism Spectrum Disorders: Guided Investigation of Social Cognitive Endophenotypes

Death by suicide occurs in a disproportionate percentage of individuals with anorexia nervosa (AN), with a standardized mortality ratio indicating a 57-fold greater risk of death from suicide relative to an age-matched cohort. Longitudinal studies indicate impaired social functioning increases risk...

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Bibliographic Details
Published in:Psychological bulletin 2007-11, Vol.133 (6), p.976-1006
Main Authors: Zucker, Nancy L, Losh, Molly, Bulik, Cynthia M, LaBar, Kevin S, Piven, Joseph, Pelphrey, Kevin A
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anorexia
Anorexia Nervosa
Anorexia Nervosa - psychology
At Risk Persons
Autism
Autism Spectrum Disorders
Autistic Disorder - psychology
Biological and medical sciences
Child
Child clinical studies
Cognition
Cognition & reasoning
Comparative Analysis
Counseling Effectiveness
Death
Death and Dying
Developmental disorders
Eating behavior disorders
Eating Disorders
Endophenotype
Genotype & phenotype
Human
Humans
Infantile autism
Information Processing
Interpersonal Competence
Interpersonal Relations
Longitudinal Studies
Marriage - psychology
Medical sciences
Mortality
Pervasive Developmental Disorders
Phenotype
Phenotypes
Psychological factors
Psychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Social Behavior
Social Cognition
Social Environment
Social interaction
Social Perception
Social psychology
Suicide
Suicides & suicide attempts
Symptoms (Individual Disorders)
Citations: Items that cite this one
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Description
Summary:Death by suicide occurs in a disproportionate percentage of individuals with anorexia nervosa (AN), with a standardized mortality ratio indicating a 57-fold greater risk of death from suicide relative to an age-matched cohort. Longitudinal studies indicate impaired social functioning increases risk for fatal outcomes, while social impairment persists following recovery. Study of social cognition in AN may elucidate impaired processes that may influence therapeutic efficacy. Symptoms of autism spectrum disorders (ASD) are overrepresented in those who evidence a chronic course. Relative to that in AN, social information processing in ASD is well characterized and may inform systematic study in AN. This article (a) reviews impaired interpersonal processes in AN, (b) compares the phenotype of AN with that of ASD, (c) highlights deficits of social cognitive disturbance in ASD relative to AN, and (d) proposes a new framework to understand the interaction of individuals with AN with their social context.
ISSN:0033-2909
1939-1455
DOI:10.1037/0033-2909.133.6.976